Dopamine D1 receptor agonist A-68930 inhibits NLRP3 inflammasome activation, controls inflammation, and alleviates histopathology in a rat model of spinal cord …
W Jiang, Y Huang, F He, J Liu, M Li, T Sun, W Ren… - Spine, 2016 - journals.lww.com
Study Design. A randomized experimental study. Objective. The aim of this study was to
investigate the therapeutic efficacy and molecular mechanisms of dopamine D1 receptor …
investigate the therapeutic efficacy and molecular mechanisms of dopamine D1 receptor …
Dopamine D1 receptor agonist A-68930 inhibits NLRP3 inflammasome activation and protects rats from spinal cord injury-induced acute lung injury
W Jiang, M Li, F He, Z Bian, J Liu, Q He, X Wang, T Sun… - Spinal cord, 2016 - nature.com
Study design: Randomized experimental study. Objectives: The study aimed to investigate
the therapeutic efficacy and molecular mechanisms of A-68930 in a rat model of spinal cord …
the therapeutic efficacy and molecular mechanisms of A-68930 in a rat model of spinal cord …
Activation of dopamine D1 receptor decreased NLRP3-mediated inflammation in intracerebral hemorrhage mice
T Wang, D Nowrangi, L Yu, T Lu, J Tang, B Han… - Journal of …, 2018 - Springer
Background Inflammasomes are involved in diverse inflammatory diseases. Previous study
reported that the neurotransmitter dopamine inhibited NLRP3 inflammasome activation via …
reported that the neurotransmitter dopamine inhibited NLRP3 inflammasome activation via …
MCC950, a selective inhibitor of NLRP3 inflammasome, reduces the inflammatory response and improves neurological outcomes in mice model of spinal cord injury
J Jiao, G Zhao, Y Wang, P Ren, M Wu - Frontiers in molecular …, 2020 - frontiersin.org
Spinal cord injury (SCI) is a serious condition that affects bodily function; however, there is
no effective therapy in clinical practice. MCC950, a selective NOD-like receptor protein-3 …
no effective therapy in clinical practice. MCC950, a selective NOD-like receptor protein-3 …
Dopamine inhibits pyroptosis and attenuates secondary damage after spinal cord injury in female mice
W Jiang, F He, G Ding, J Wu - Neuroscience Letters, 2023 - Elsevier
Background An excessive inflammatory response accompanies the pathogenesis of spinal
cord injury (SCI) and has been found to be promoted by inflammasomes in a variety of …
cord injury (SCI) and has been found to be promoted by inflammasomes in a variety of …
Dopamine D1 receptor agonist A-68930 ameliorates Aβ1-42-induced cognitive impairment and neuroinflammation in mice
ZY Cheng, QP Xia, YH Hu, C Wang, L He - International …, 2020 - Elsevier
Alzheimer's disease (AD) is an irreversible neurodegenerative disease characterized by
progressive cognitive dysfunction and memory impairment. Dopamine is an important …
progressive cognitive dysfunction and memory impairment. Dopamine is an important …
Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury
J Amo-Aparicio, J Garcia-Garcia… - Experimental …, 2022 - Elsevier
Spinal cord injury (SCI) leads to irreversible functional deficits due to the disruption of axons
and the death of neurons and glial cells. The inflammatory response that occurs in the …
and the death of neurons and glial cells. The inflammatory response that occurs in the …
MCC950 reduces neuronal apoptosis in spinal cord injury in mice
N He, X Zheng, T He, G Shen, K Wang… - CNS & Neurological …, 2021 - ingentaconnect.com
Background: Traumatic Spinal Cord Injury (SCI) is a severe condition usually accompanied
by an inflammatory process that gives rise to uncontrolled local apoptosis and a subsequent …
by an inflammatory process that gives rise to uncontrolled local apoptosis and a subsequent …
Anti-inflammatory effects of dopamine in lipopolysaccharide (LPS)-stimulated RAW264. 7 cells via inhibiting NLRP3 inflammasome activation
A Liu, S Ding - Annals of Clinical & Laboratory Science, 2019 - Assoc Clin Scientists
Objective Dopamine (DA) is a neurotransmitter and chemical mediator, and DA receptors
(particularly DRD1) are present on the majority of immune cells. The aim of this study was to …
(particularly DRD1) are present on the majority of immune cells. The aim of this study was to …
Paeonol regulates NLRP3 inflammasomes and pyroptosis to alleviate spinal cord injury of rat
H Zhao, X Wang, S Liu, Q Zhang - BMC neuroscience, 2022 - Springer
Background Spinal cord injury (SCI) is a life-threatening traumatic disorder. Paeonol has
been confirmed to be involved in a variety of diseases. The purpose of this study is to …
been confirmed to be involved in a variety of diseases. The purpose of this study is to …
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