The functions of the high-affinity glycine transporters (GLYTs) in vivo have been revealed
recently using gene-deletion studies. Results from studies of homozygous knockout mice …

Glycine has important neurotransmitter functions at inhibitory and excitatory synapses in the
vertebrate central nervous system. The effective synaptic concentrations of glycine are …

J. Neurochem.(2010) 114, 647–653. Abstract Glycine transporter 1 (GLYT1) and GLYT2 are
the glycine transporters in CNS. While GLYT2 is largely expressed in glycinergic neurons …

Introduction. Glycine is one of the major inhibitory neurotransmitters in the spinal cord and
brain stem of vertebrates. 1 The inhibitory actions of glycine are mediated by the strychnine …

High-affinity glycine transport in neurons and glial cells is a primary means of inactivating
synaptic glycine. We have synthesized a potent selective inhibitor of glycine transporter 1 …

Glycine acts as an inhibitory neurotransmitter at glycine receptor (GlyR)-enriched synapses
and as an obligatory co-agonist at the N-methyl-D-aspartate (NMDA) receptor, where it …

The amino acid glycine (Gly) serves as a neurotransmitter at excitatory and inhibitory
synapses in the mammalian central nervous system. Gly concentrations at post-synaptic …

The glycine transporter subtype 1 (GlyT1) is widely expressed in astroglial cells throughout
the mammalian central nervous system and has been implicated in the regulation of N …

The human glycine transporter type 2 (hGlyT2) was cloned from a spinal cord cDNA library
using PCR-based methodologies. The isolated sequence exhibits 89% homology with the …

Abstract Glycine transporters (GlyTs) are Na+/Cl−-dependent neurotransmitter transporters,
responsible for l-glycine uptake into the central nervous system. GlyTs are members of the …