The simple amino acid glycine is implicated in both inhibitory and excitatory
neurotransmission in mammalian central nervous system, and it modulates excitatory …

It is widely accepted that glycine transporters of the GLYT1 type are situated on astrocytes
whereas GLYT2 are present on glycinergic neuronal terminals where they mediate glycine …

In the central nervous system, glutamate is essential for a proper synaptic communication in
neuronal networks supporting critical behavioral activities such as learning and memory …

In the central nervous system, glycine is a co-agonist with glutamate at the N-methyl-d-
aspartate subtype of glutamate receptors and also an agonist at inhibitory, strychnine …

Summary The glycine transporter 1 (GlyT1) plays a crucial role in the regulation of both
inhibitory and excitatory neurotransmission by removing glycine from the synaptic cleft …

Glycine is the major inhibitory neurotransmitter in brainstem and spinal cord, whereas in
hippocampus glycine exerts dual modulatory roles on strychnine-sensitive glycine receptors …

Inhibitory glycinergic neurotransmission is terminated by sodium and chloride-dependent
plasma membrane glycine transporters (GlyTs). The mainly glial glycine transporter GlyT1 is …

A novel glycine transporter (GLYT2) was cloned from a rat brain cDNA library. GLYT2 is
about 48 and 50% homologous to the previously cloned mouse glycine transporter (GLYT1) …

The rat GLYT-1 gene encodes two glycine transporter variants, GLYT-1a and GLYT-1b, that
differ in NH 2 termini and 5′-noncoding regions as well as in tissue distribution. The GLYT …

The neuronal glycine transporter GLYT2 takes up glycine from the extracellular space by an
electrogenic process where this neurotransmitter is co-transported with sodium and chloride …