Selective destabilization of short-lived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich 3'noncoding region is mediated by a cotranslational …
T Aharon, RJ Schneider - Molecular and cellular biology, 1993 - Am Soc Microbiol
The 3'noncoding region element (AUUUA) n specifically targets many short-lived mRNAs for
degradation. Although the mechanism by which this sequence functions is not yet …
degradation. Although the mechanism by which this sequence functions is not yet …
Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a> 20S degradation complex.
S Savant-Bhonsale, DW Cleveland - Genes & development, 1992 - genesdev.cshlp.org
Many short-lived mRNAs, including those encoding lymphokines, cytokines, and proto-
oncogenes, contain an AU-rich sequence in their 3'-untranslated regions. These AU …
oncogenes, contain an AU-rich sequence in their 3'-untranslated regions. These AU …
Functional characterization of a non-AUUUA AU-rich element from the c-jun proto-oncogene mRNA: evidence for a novel class of AU-rich elements
SSY Peng, CYA Chen, AB Shyu - Molecular and cellular biology, 1996 - Am Soc Microbiol
AU-rich RNA-destabilizing elements (AREs) found in the 3′ untranslated regions of many
labile mRNAs encoding proto-oncoproteins and cytokines generally contain (i) one or more …
labile mRNAs encoding proto-oncoproteins and cytokines generally contain (i) one or more …
Rapid degradation of AU-rich element (ARE) mRNAs is activated by ribosome transit and blocked by secondary structure at any position 5′ to the ARE
AM Curatola, MS Nadal… - Molecular and cellular …, 1995 - Taylor & Francis
The 3′ noncoding region (NCR) AU-rich element (ARE) selectively confers rapid
degradation on many mRNAs via a process requiring translation of the message. The role of …
degradation on many mRNAs via a process requiring translation of the message. The role of …
AUUUA is not sufficient to promote poly (A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA (U/A)(U/A)
CA Lagnado, CY Brown, GJ Goodall - Molecular and cellular …, 1994 - Am Soc Microbiol
AU-rich elements (AREs) in the 3′ untranslated regions of several cytokine and oncogene
mRNAs have been shown to function as signals for rapid mRNA degradation, and it is …
mRNAs have been shown to function as signals for rapid mRNA degradation, and it is …
A 32-kilodalton protein binds to AU-rich domains in the 3′ untranslated regions of rapidly degraded mRNAs
E Vakalopoulou, J Schaack… - Molecular and cellular …, 1991 - Am Soc Microbiol
An AU-rich sequence present within the 3′ untranslated region has been shown to mark
some short-lived mRNAs for rapid degradation. We demonstrate by label transfer and gel …
some short-lived mRNAs for rapid degradation. We demonstrate by label transfer and gel …
The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation
AM Zubiaga, JG Belasco… - Molecular and cellular …, 1995 - Am Soc Microbiol
Labile mRNAs that encode cytokine and immediate-early gene products often contain AU-
rich sequences within their 3′ untranslated region (UTR). These AU-rich sequences …
rich sequences within their 3′ untranslated region (UTR). These AU-rich sequences …
mRNA Decay Mediated by Two Distinct AU-Rich Elements from c-fos and Granulocyte-Macrophage Colony-Stimulating Factor Transcripts: Different Deadenylation …
CYA Chen, N Xu, AB Shyu - Molecular and cellular biology, 1995 - Taylor & Francis
Poly (A) tail removal is a critical first step in the decay pathway for many yeast and
mammalian mRNAs. Poly (A) shortening rates can be regulated by cis-acting sequences …
mammalian mRNAs. Poly (A) shortening rates can be regulated by cis-acting sequences …
5′ untranslated sequences modulate rapid mRNA degradation mediated by 3′ AU-rich element in v-/c- fos recombinants
N Roy, G Laflamme, V Raymond - Nucleic acids research, 1992 - academic.oup.com
One major determinant of rapid mRNA decay is the presence of AU-rich sequences located
in 3′ untranslated regions (UTR). To assess for the contribution of upstream sequences on …
in 3′ untranslated regions (UTR). To assess for the contribution of upstream sequences on …
Possible involvement of proteasomes (prosomes) in AUUUA-mediated mRNA decay
AS Jarrousse, F Petit, C Kreutzer-Schmid… - Journal of Biological …, 1999 - ASBMB
We have identified a cellular target for proteasomal endonuclease activity. Thus, 20 S
proteasomes interact with the 3′-untranslated region of certain cytoplasmic mRNAs in vivo …
proteasomes interact with the 3′-untranslated region of certain cytoplasmic mRNAs in vivo …