Pharmacological rescue of nociceptive hypersensitivity and oxytocin analgesia impairment in a rat model of neonatal maternal separation

M Melchior, PE Juif, G Gazzo, N Petit-Demoulière… - Pain, 2018 - journals.lww.com
Oxytocin (OT), known for its neurohormonal effects around birth, has recently been
suggested for being a critical determinant in neurodevelopmental disorders. This …

Experiencing neonatal maternal separation increased pain sensitivity in adult male mice: involvement of oxytocinergic system

H Amini-Khoei, S Amiri, A Mohammadi-Asl… - Neuropeptides, 2017 - Elsevier
Early-life stress adversely affects the development of the brain, and alters a variety of
behaviors such as pain in later life. In present study, we investigated how early-life stress …

Oxytocin signaling in pain: cellular, circuit, system, and behavioral levels

P Poisbeau, V Grinevich, A Charlet - Behavioral pharmacology of …, 2018 - Springer
Originally confined to the initiation of parturition and milk ejection after birth, the
hypothalamic nonapeptide oxytocin (OT) is now recognized as a critical determinant of …

Oxytocin pathways in the intergenerational transmission of maternal early life stress

P Toepfer, C Heim, S Entringer, E Binder… - Neuroscience & …, 2017 - Elsevier
Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk
factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long …

[HTML][HTML] Newborn analgesia mediated by oxytocin during delivery

M Mazzuca, M Minlebaev, A Shakirzyanova… - Frontiers in cellular …, 2011 - frontiersin.org
The mechanisms controlling pain in newborns during delivery are poorly understood. We
explored the hypothesis that oxytocin, an essential hormone for labor and a powerful …

Dysfunctions of brain oxytocin signaling: implications for poor mothering

A Sanson, OJ Bosch - Neuropharmacology, 2022 - Elsevier
Good mothering has profound impact on both the mother's and the young's well-being.
Consequently, experiencing inadequate maternal care–or even neglect–in the first stages of …

Intranasal oxytocin administration facilitates the induction of long-term potentiation and promotes cognitive performance of maternally separated rats

S Joushi, K Esmaeilpour, Y Masoumi-Ardakani… - …, 2021 - Elsevier
Maternal separation (MS) is known to induce permanent changes in the central nervous
system and is associated with increased levels of anxiety and cognitive impairments. The …

Neuroactive steroids attenuate oxytocin stress responses in late pregnancy

JA Russell, PJ Brunton - Neuroscience, 2006 - Elsevier
In late pregnant rats neuroendocrine stress responses, expressed as increased oxytocin
secretion and activation of the hypothalamo–pituitary–adrenal axis, are attenuated. These …

[HTML][HTML] The role of oxytocin and the effect of stress during childbirth: neurobiological basics and implications for mother and child

MH Walter, H Abele, CF Plappert - Frontiers in endocrinology, 2021 - frontiersin.org
The neuropeptide oxytocin acts as a hormone and a neuromodulator, influencing a
multitude of human social behaviors, including reproduction. During childbirth and the …

Neuropeptides as neuroprotective agents: Oxytocin a forefront developmental player in the mammalian brain

F Vargas-Martinez, K Uvnäs-Moberg… - Progress in …, 2014 - Elsevier
Oxytocin (OT) plays a major role in the establishment of social bonds. Social bonds are
linked to the activation of cell signaling pathways that promote neurotrophic and synaptic …