Colistin is the last line of defense for the treatment of multidrug-resistant gram-negative
bacterial infections. However, colistin resistance is gradually increasing worldwide, with …

The emergence of the plasmid-mediated colistin resistance gene mcr-1 is threatening the
last-line role of colistin in human medicine. With mcr-1-positive Escherichia coli (E. coli) …

Objectives This study investigated the prevalence and characteristics of mcr-1-harbouring
Escherichia coli isolated from chickens in central China from 2014 to 2019. Methods A total …

Colistin is used to treat infectious diseases in humans and livestock; it has also been used
as a feed additive for livestock for approximately 50 years. Since the mcr-1 plasmid …

The objective of this study was to determine the minimal inhibitory concentration of colistin
for Escherichia coli from food animals and the possible underlying colistin resistance …

Increasing colistin resistance is a global concern because colistin is used as a last resort for
the treatment of carbapenem-resistant Enterobacteriaceae infections. The plasmid-mediated …

Antimicrobial resistance to colistin has emerged worldwide threatening the efficacy of one of
the last-resort antimicrobials used for the treatment of multidrug-resistant Enterobacteriacea …

Colistin is one of the last-resort antibiotics for treating infections caused by multidrug-
resistant (MDR) Gram-negative bacteria. However, mcr genes conferring resistance to …

The global dissemination of colistin resistance has received a great deal of attention.
Recently, the plasmid-mediated colistin resistance encoded by mcr genes in Escherichia …

Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-
resistant Gram-negative bacterial infections. The recent global dissemination of mobilized …