Possessing a discrete functional repertoire, the anterior horn cell can be in one of two
electrophysiological states: on or off. Usually under tight regulatory control by the central …

Abstract Introduction/Aims In amyotrophic lateral sclerosis (ALS), the impact of motor neuron
dysfunction on the motor unit (MU) firing pattern remains to be elucidated. The aim of this …

See article on pages 149–156 in this issue.

We hypothesized that action potentials evoked by distal stimulation might trigger ectopic
activity (multiplet discharges, MDs). By studying MDs, we investigated the involvement of the …

Objective To determine whether cortical hyperexcitability preceded the development of
lower motor neuron (LMN) dysfunction in sporadic amyotrophic lateral sclerosis (ALS) …

Neuronal and/or axonal hyperactivity and hyperexcitability is an important feature of motor
neuron diseases. It results clinically in cramps and fasciculations. It is not specific to motor …

A collision experiment has been used to investigate repetitive firing of first dorsal
interosseous motoneurons following a single transcranial magnetic stimulus (TMS) in …

Neuromyotonic and myokymic discharges are abnormal electrical muscular discharges
caused by ectopic discharges from motor axons and represent the hallmarks of peripheral …

Neuronal hyperexcitability is a well-known phenomenon in amyotrophic lateral sclerosis and
other neurodegenerative diseases. The use of transcranial magnetic stimulation in clinical …

Background and purpose Amyotrophic lateral sclerosis (ALS) is characterized by focal
disease onset with a predominantly contiguous pattern of disease spread. The …