Glutamatergic treatment strategies for age-related memory disorders

WE Müller, K Scheuer, S Stoll - Life sciences, 1994 - Elsevier
Age-related changes of N-methyl-D-aspartate (NMDA) receptors have been found in cortical
areas and in the hippocampus of many species. On the basis of a variety of experimental …

[图书][B] The function of the NMDA-receptor during normal brain aging

WE Müller, S Stoll, K Scheuer, A Meichelböck - 1994 - Springer
Age-related changes of N-methyl-D-aspartate (NMDA) receptors have been found in cortical
areas and in the hippocampus of many species. On the basis of a variety of experimental …

NMDA receptor activation in the aged rat: electrophysiological investigations in the CA1 area of the hippocampal slice ex vivo

JM Billard, A Jouvenceau, Y Lamour, P Dutar - Neurobiology of aging, 1997 - Elsevier
The effects of aging on activation of N-methyl-d-aspartate (NMDA) receptors were studied in
the CA1 field of hippocampal slices from young (2–4 months old) and aged (25–32 months …

Deficit of NMDA receptor activation in CA1 hippocampal area of aged rats is rescued by d‐cycloserine

JM Billard, E Rouaud - European Journal of Neuroscience, 2007 - Wiley Online Library
Activation of the glycine modulatory site of the N‐methyl‐d‐aspartate glutamate receptor
(NMDAR) may reduce cognitive impairments associated with normal ageing. In order to test …

Age-related alterations of NMDA-receptor properties in the mouse forebrain: partial restoration by chronic phosphatidylserune treatment

SA Cohen, WE Mu - Brain research, 1992 - Elsevier
The effect of aging on the properties of N-methyl-d-aspartate (NMDA) receptors in the
forebrain of female NMRI mice was investigated using the antagonist [3 H] MK-801 as …

[PDF][PDF] The aging of the NMDA receptor complex

KR Magnusson - Front Biosci, 1998 - article.imrpress.com
1. ABSTRACT N-methyl-D-aspartate (NMDA) receptors are present at high density in the
cerebral cortex and hippocampus and play an important role in learning and memory. These …

Rodent models of memory dysfunction in Alzheimer's disease and normal aging: moving beyond the cholinergic hypothesis

DK Ingram, EL Spangler, S Iijima, H Ikari, H Kuo… - Life sciences, 1994 - Elsevier
The Stone maze paradigm has been developed for use as a rat model of memory
impairment observed in normal aging and in Alzheimer's disease. Results from several …

NMDA receptor activation in the aged rat hippocampus

B Potier, F Poindessous-Jazat, P Dutar… - Experimental gerontology, 2000 - Elsevier
Age-related alterations of N-methyl-d-aspartate receptor (NMDAr) activation were
investigated in the CA1 field of hippocampal slices from young (3–6 months old) and aged …

N-methyl-D-aspartate mediated responses decrease with age in Fischer 344 rat brain

RA Gonzales, LM Brown, TW Jones, RD Trent… - Neurobiology of …, 1991 - Elsevier
N-Methyl-D-aspartate (NMDA) receptor-mediated responses were studied in hippocampus,
cortex, and striatum of Fischer 344 rats of various ages (3–5, 12–14, or 24–28 months old; …

The co-agonist site of NMDA-glutamate receptors: a novel therapeutic target for age-related cognitive decline

R Panizzutti, L Scoriels, M Avellar - Current pharmaceutical …, 2014 - ingentaconnect.com
The world population is growing older and age-related cognitive decline is becoming a
burden of societal importance. D-serine is an endogenous amino acid that activates the co …