Seven normal awake males were studied to define the mechanisms and impact of lung
volume on the hypoxemia occurring during apnea. During repeated 30-s voluntary breath …

The mechanisms responsible for the development of chronic hypercapnia in patients with
obstructive sleep apnea (OSA) are not well defined. Therefore, we tested the hypothesis that …

We studied 18 patients with obstructive sleep apnea (OSA). Each subject slept while
breathing through the nose with a specially designed valveless breathing circuit. Low levels …

Because flow-volume loops (FVLs) are clinically useful In evaluating upper airway (UA)
obstruction and the fact that patency of the nasopharyngeal ventilatory pathway Is Important …

To determine whether there is a relationship between pharyngeal airway collapsibility in
awake subjects with obstructive sleep apnea (OSA) and the degree of disordered breathing …

We previously showed that upper airway resistance can be inferred from the inspiratory flow
contour during continuous positive airway pressure (CPAP) titration in obstructive sleep …

Rationale: There is increasing evidence of increased ventilatory instability in patients with
obstructive sleep apnea (OSA), but previous investigations have not studied whether the …

To assess the effect of sleep on functional residual capacity (FRC) in normal subjects and
asthmatic patients, 10 adult subjects (5 asthmatic patients with nocturnal worsening, 5 …

In order to determine the specific site of inspiratory narrowing within the upper airway during
sleep, we measured supralaryngeal, oropharyngeal, and nasopharyngeal pressures and …

Background The increase in peripheral chemoreflex sensitivity in patients with obstructive
sleep apnea (OSA) is associated with activation of autonomic nervous system and …