Manganese neurotoxicity and the role of reactive oxygen species

EJ Martinez-Finley, CE Gavin, M Aschner… - Free radical biology and …, 2013 - Elsevier
Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic.
Disease states, such as manganism, are associated with overexposure or accumulation of …

Manganese: its role in disease and health

KM Erikson, M Aschner - Met. Ions Life Sci, 2019 - degruyter.com
Manganese is an essential dietary element that functions primarily as a coenzyme in several
biological processes. These processes include, but are not limited to, macronutrient …

[HTML][HTML] Manganese accumulation in the brain via various transporters and its neurotoxicity mechanisms

I Nyarko-Danquah, E Pajarillo, A Digman, KFA Soliman… - Molecules, 2020 - mdpi.com
Manganese (Mn) is an essential trace element, serving as a cofactor for several key
enzymes, such as glutamine synthetase, arginase, pyruvate decarboxylase, and …

The impact of manganese on neurotransmitter systems

ATG Soares, A de Castro Silva, AA Tinkov… - Journal of Trace …, 2020 - Elsevier
Abstract Background Manganese (Mn) is a metal ubiquitously present in nature and
essential for many living organisms. As a trace element, it is required in small amounts for …

[HTML][HTML] Brain manganese and the balance between essential roles and neurotoxicity

RC Balachandran, S Mukhopadhyay, D McBride… - Journal of Biological …, 2020 - ASBMB
Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …

The effects of manganese overexposure on brain health

MR Miah, OM Ijomone, COA Okoh, OK Ijomone… - Neurochemistry …, 2020 - Elsevier
Manganese (Mn) is the twelfth most abundant element on the earth and an essential metal
to human health. Mn is present at low concentrations in a variety of dietary sources, which …

Manganese homeostasis in the nervous system

P Chen, S Chakraborty… - Journal of …, 2015 - Wiley Online Library
Manganese (Mn) is an essential heavy metal that is naturally found in the environment. Daily
intake through dietary sources provides the necessary amount required for several key …

Manganese and the brain

K Tuschl, PB Mills, PT Clayton - International review of neurobiology, 2013 - Elsevier
Manganese (Mn) is an essential trace metal that is pivotal for normal cell function and
metabolism. Its homeostasis is tightly regulated; however, the mechanisms of Mn …

The impact of environmental and occupational exposures of manganese on pulmonary, hepatic, and renal functions

D Gandhi, AP Rudrashetti… - Journal of Applied …, 2022 - Wiley Online Library
Manganese (Mn) is an essential trace element for humans, but long‐term environmental or
occupational exposures can lead to numerous health problems. Although many studies …

Manganese: pharmacokinetics and molecular mechanisms of brain uptake

M Aschner, DC Dorman - Toxicological reviews, 2006 - Springer
Manganese is an essential mineral that is found at low levels in virtually all diets.
Manganese ingestion represents the principal route of human exposure, although inhalation …