Mangiferin alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome …

C Pan, Z Pan, J Hu, W Chen, G Zhou, W Lin… - European journal of …, 2016 - Elsevier
Mangiferin, a glucosylxanthone from Mangifera indica, has been reported to have anti-
inflammatory effects. However, the protective effects and mechanisms of mangiferin on liver …

Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2–NFκB pathways

J Das, J Ghosh, A Roy, PC Sil - Toxicology and applied pharmacology, 2012 - Elsevier
Mangiferin, a xanthone glucoside, is well known to exhibit antioxidant, antiviral, antitumor,
anti-inflammatory and gene-regulatory effects. In the present study, we isolated mangiferin …

Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome …

X Liu, T Wang, X Liu, L Cai, J Qi, P Zhang… - International …, 2016 - Elsevier
Biochanin A, an isoflavone existed in red clover and peanuts, has been reported to possess
a wide spectrum of pharmacological activities, such as anti-inflammatory and antioxidant …

Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy

H Fan, J Cui, F Liu, W Zhang, H Yang, N He… - European Journal of …, 2022 - Elsevier
Sepsis-related acute liver injury (ALI) is a fatal disease associated with many complications.
Recent studies indicate that malvidin, an active flavonoid, has multiple bioactivities including …

Mangiferin mitigates lipopolysaccharide-induced lung injury by inhibiting NLRP3 inflammasome activation

N Li, R Xiong, R He, B Liu, B Wang… - Journal of Inflammation …, 2021 - Taylor & Francis
Scope Mangiferin (MF) is a natural phytopolyphenol, which displays potential
pharmacological properties involving antibacterial, anti-inflammation, antioxidant and anti …

Genipin protects d-galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the necroptosis-mediated inflammasome signaling

MJ Seo, JM Hong, SJ Kim, SM Lee - European journal of pharmacology, 2017 - Elsevier
Acute liver failure (ALF) is a life-threatening syndrome resulting from massive inflammation
and hepatocyte death. Necroptosis, a programmed cell death controlled by receptor …

[HTML][HTML] Amygdalin attenuates acute liver injury induced by D-galactosamine and lipopolysaccharide by regulating the NLRP3, NF-κB and Nrf2/NQO1 signalling …

F Tang, K Fan, K Wang, C Bian - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Acute liver injury (ALI) is a life-threatening syndrome accompanied by overwhelming
inflammation. Amygdalin (AGD) has been reported to possess various biological activities …

Baicalein attenuates acute liver injury by blocking NLRP3 inflammasome

T Xiao, Y Cui, H Ji, L Yan, D Pei, S Qu - Biochemical and biophysical …, 2021 - Elsevier
Infection and/or drug-mediated acute liver injury, the leading cause of lethal liver failure, is a
critical health problem worldwide and lacks effective treatment. Here, we used …

Isoliquiritigenin alleviates LPS/D-GalN-induced acute liver failure by activating the PGC-1α/Nrf2 pathway to reduce oxidative stress and inflammatory response

L Wang, X Wang, L Kong, S Wang, K Huang… - International …, 2021 - Elsevier
Acute liver failure (ALF) is a dramatic liver disease characterized by large areas of
inflammation. However, there are no available effective targeted drugs for ALF treatment. In …