Therapy of mitochondria-targeted hybrid nanozymes for reactive oxygen species-induced diseases

Z Wang, Z Shen, S Lin, X Mei - Applied Materials Today, 2023 - Elsevier
The development of enzyme mimetics that clear excess mitochondrial reactive oxidative
stress (ROS) could provide effective treatment for a wide variety of diseases. Herein …

Biomimetic Design of Mitochondria‐Targeted Hybrid Nanozymes as Superoxide Scavengers

Y Zhang, A Khalique, X Du, Z Gao, J Wu… - Advanced …, 2021 - Wiley Online Library
Abstract Development of enzyme mimics for the scavenging of excessive mitochondrial
superoxide (O2•−) can serve as an effective strategy in the treatment of many diseases …

Antioxidant activities of metal single-atom nanozymes in biomedicine

Q Zeng, H Zhong, J Liao, Q Huo, B Miao, L Zeng… - Biomaterials …, 2024 - pubs.rsc.org
Nanozymes are a class of nanomaterials with enzyme-like activity that can mimic the
catalytic properties of natural enzymes. The small size, high catalytic activity, and strong …

[HTML][HTML] A histidine-functionalized ROS scavenging hybrid nanozyme for therapeutic application in Parkinson's disease pathogenesis

S Prasad, PS Nayak, P D'Silva - Materials Advances, 2024 - pubs.rsc.org
Oxidative stress-mediated neurotoxicity is one of the significant molecular consequences in
the progression of neurodegenerative diseases like Parkinson's disease (PD). Although …

Nanozymes targeting mitochondrial repair in disease treatment

Y Zhang, S Ma, W Chang, W Yu, L Zhang - Journal of Biotechnology, 2024 - Elsevier
Mitochondria are crucial sites for biological oxidation and substance metabolism and plays a
vital role in maintaining intracellular homeostasis. When mitochondria undergo oxidative …

Multi-shell nanocomposites based multienzyme mimetics for efficient intracellular antioxidation

Y Ai, J You, J Gao, J Wang, H Sun, M Ding, Q Liang - Nano Research, 2021 - Springer
Oxidative stress is associated with many acute and chronic inflammatory diseases.
Development of nanomaterial-based enzyme mimetics for reactive oxygen species (ROS) …

Incorporation of a biocompatible nanozyme in cellular antioxidant enzyme cascade reverses huntington's like disorder in preclinical model

A Adhikari, S Mondal, M Das, P Biswas… - Advanced …, 2021 - Wiley Online Library
The potentiality of nano‐enzymes in therapeutic use has directed contemporary research to
develop a substitute for natural enzymes, which are suffering from several disadvantages …

[HTML][HTML] Rational design and biological application of antioxidant nanozymes

R Tian, J Xu, Q Luo, C Hou, J Liu - Frontiers in chemistry, 2021 - frontiersin.org
Nanozyme is a type of nanostructured material with intrinsic enzyme mimicking activity,
which has been increasingly studied in the biological field. Compared with natural enzymes …

Nanozyme-based medicine for enzymatic therapy: progress and challenges

Q Wang, J Jiang, L Gao - Biomedical Materials, 2021 - iopscience.iop.org
Nanozymes are nanomaterials with enzyme-like characteristics. As a new generation of
artificial enzymes, nanozymes have the advantages of low cost, good stability, simple …

[HTML][HTML] Recent trends in composite nanozymes and their pro-oxidative role in therapeutics

S Maddheshiya, S Nara - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Nanozymes are inorganic nanostructures whose enzyme mimic activities are increasingly
explored in disease treatment, taking inspiration from natural enzymes. The catalytic ability …