Exposure to a high-fat (HF) diet in utero is associated with increased incidence of
cardiovascular disease, diabetes, and metabolic syndrome later in life. However, the …

Aim: We investigate how postweaning diet may modify the epigenetic landscape to meet
metabolic demands later in life. Methods: Sprague-Dawley rats were exposed to a high-fat …

Objective: Maternal obesity significantly increases the susceptibility of offspring to develop
obesity and chronic diseases in adulthood. The offspring of obese mothers are shown to …

The association between an adverse early life environment and increased susceptibility to
later-life metabolic disorders such as obesity, type 2 diabetes and cardiovascular disease is …

An epigenetic mechanism has been suggested to explain the effects of the maternal diet on
the development of disease in offspring. The present study aimed to observe the effects of a …

Objective Data from animal models show that in utero exposure to a maternal high-fat diet
(HFD) renders susceptibility of these offspring to the adult onset of metabolic syndrome. We …

Scope: Overnutrition in utero is a critical contributor to the susceptibility of diabetes by
programming, although the exact mechanism is not clear. In this paper, we aimed to study …

It has long been established that an adverse maternal condition impacts on the developing
fetus and predisposes the offspring to develop metabolic and cardiovascular disease in later …

Prenatal nutritional constraint induces an altered metabolic phenotype in the offspring which
in humans confers an increased risk of non-communicable disease. Feeding a protein …

We investigated maternal obesity in inbred SM/J mice by assigning females to a high-fat diet
or a low-fat diet at weaning, mating them to low-fat-fed males, cross-fostering the offspring to …