Phenotypes and treatment response: it's difficult to make predictions, especially about the future
RH Dworkin, RR Edwards - Pain, 2017 - journals.lww.com
Over 25 years ago, Mitchell Max proposed that “more effective, less toxic treatments” could
be developed by targeting the specific pathophysiologic mechanisms that account for …
be developed by targeting the specific pathophysiologic mechanisms that account for …
Interpreting patient treatment response in analgesic clinical trials: implications for genotyping, phenotyping, and personalized pain treatment
RH Dworkin, MP McDermott, JT Farrar, AB O'Connor… - PAIN®, 2014 - Elsevier
When interpreting the results of randomized clinical trials (RCTs) of efficacious pain
treatments, it is commonly concluded that some patients have responded to treatment …
treatments, it is commonly concluded that some patients have responded to treatment …
Mechanism-based treatment of pain
RH Dworkin - Pain, 2012 - journals.lww.com
In a recent commentary, Sindrup et al. state that ''A mechanism-based approach to the
treatment of neuropathic pain was, in fact, suggested more than a decade ago''[2]. An …
treatment of neuropathic pain was, in fact, suggested more than a decade ago''[2]. An …
Mechanisms of disease: neuropathic pain—a clinical perspective
R Baron - Nature clinical practice Neurology, 2006 - nature.com
Neuropathic pain syndromes—pain after a lesion or disease of the peripheral or central
nervous system—are clinically characterized by spontaneous and evoked types of pain …
nervous system—are clinically characterized by spontaneous and evoked types of pain …
Evidence-based clinical trial design for chronic pain pharmacotherapy: a blueprint for ACTION
Although considerable progress has been made in identifying pathophysiologic
mechanisms of acute and chronic pain, this knowledge has not translated to the …
mechanisms of acute and chronic pain, this knowledge has not translated to the …
[HTML][HTML] Is mechanism-based pain treatment attainable? Clinical trial issues
MB Max - The Journal of Pain, 2000 - Elsevier
Woolf et al have recently called for the development of a mechanism-based pain taxonomy
to guide the individualization of treatment based on each patient's pain mechanisms …
to guide the individualization of treatment based on each patient's pain mechanisms …
Pharmacogenetics in pain management: the clinical need
LR Webster - Clinics in laboratory medicine, 2008 - Elsevier
Genetic research heralds a new therapeutic approach to pain management. Increasing
literature demonstrates individual genetic vulnerabilities to specific pain types and …
literature demonstrates individual genetic vulnerabilities to specific pain types and …
Navigating trials of personalized pain treatments: we're going to need a bigger boat
JS Gewandter, MP McDermott, O Mbowe, RR Edwards… - Pain, 2019 - journals.lww.com
Personalized or precision treatments are targeted therapies that are particularly effective or
have reduced harms for a subgroup of patients within a given condition. 3 This type of …
have reduced harms for a subgroup of patients within a given condition. 3 This type of …
Individual responder analyses for pain: does one pain scale fit all?
RA Dionne, L Bartoshuk, J Mogil, J Witter - Trends in pharmacological …, 2005 - cell.com
The outcomes of clinical trials are based on the mean responses of large numbers of
subjects but fail to address inter-individual differences. The molecular mechanisms that …
subjects but fail to address inter-individual differences. The molecular mechanisms that …
Personalized therapy in pain management: where do we stand?
UM Stamer, L Zhang, F Stüber - Pharmacogenomics, 2010 - Taylor & Francis
Genomic variations influencing response to pharmacotherapy of pain are currently under
investigation. Drug-metabolizing enzymes represent a major target of ongoing research in …
investigation. Drug-metabolizing enzymes represent a major target of ongoing research in …