Over 25 years ago, Mitchell Max proposed that “more effective, less toxic treatments” could
be developed by targeting the specific pathophysiologic mechanisms that account for …

When interpreting the results of randomized clinical trials (RCTs) of efficacious pain
treatments, it is commonly concluded that some patients have responded to treatment …

In a recent commentary, Sindrup et al. state that ''A mechanism-based approach to the
treatment of neuropathic pain was, in fact, suggested more than a decade ago''[2]. An …

Neuropathic pain syndromes—pain after a lesion or disease of the peripheral or central
nervous system—are clinically characterized by spontaneous and evoked types of pain …

Although considerable progress has been made in identifying pathophysiologic
mechanisms of acute and chronic pain, this knowledge has not translated to the …

Woolf et al have recently called for the development of a mechanism-based pain taxonomy
to guide the individualization of treatment based on each patient's pain mechanisms …

Genetic research heralds a new therapeutic approach to pain management. Increasing
literature demonstrates individual genetic vulnerabilities to specific pain types and …

Personalized or precision treatments are targeted therapies that are particularly effective or
have reduced harms for a subgroup of patients within a given condition. 3 This type of …

The outcomes of clinical trials are based on the mean responses of large numbers of
subjects but fail to address inter-individual differences. The molecular mechanisms that …

Genomic variations influencing response to pharmacotherapy of pain are currently under
investigation. Drug-metabolizing enzymes represent a major target of ongoing research in …