Limited data exist for appropriate drug dosing in obese children. This comprehensive review
summarizes pharmacokinetic (PK) alterations that occur with age and obesity, and these …

Studies evaluating the outcomes of an extended-infusion (EI) piperacillin-tazobactam dosing
strategy in specific cohorts of critically ill patients are lacking. A retrospective, pre …

Critical illness caused by burn and sepsis is associated with pathophysiologic changes that
may result in the alteration of pharmacokinetics (PK) of antibiotics. However, it is unclear if …

The pharmacokinetics of tazobactam (500 mg) administered intravenously alone were
compared with the pharmacokinetics of tazobactam coadministered with piperacillin (4 g) …

Abstract Background and Objective Piperacillin is a broad-spectrum β-lactam antibiotic
commonly prescribed in intensive care units. Many piperacillin population pharmacokinetic …

Objective The purpose of this study is to evaluate the outcome differences between patients
receiving piperacillin-tazobactam pre-and post-implementation of an extended infusion …

Administration of β-lactam antibiotics by extended infusion optimizes the pharmacodynamic
properties and bactericidal activity of these agents resulting in a potential improvement in …

Piperacillin/tazobactam, an intravenous antibacterial combination product, has recently
been approved for paediatric (age 2 months to 17 years) use in the USA. The purpose of this …

BACKGROUND: Use of extended infusions of piperacillin/tazobactam (PT) in adult patients
has been described, but data in children are limited. OBJECTIVE: The goal of this study was …

Background: Current medical center practice allows for the automatic conversion of all
piperacillin/tazobactam orders from intermittent to extended infusion (EI). Objective: To …