Lipoprotein (a) levels in familial hypercholesterolemia: an important predictor of cardiovascular disease independent of the type of LDL receptor mutation

R Alonso, E Andres, N Mata, F Fuentes-Jiménez… - Journal of the American …, 2014 - jacc.org
Objectives: The aim of this study was to determine the relationship between lipoprotein
(a)[Lp (a)] and cardiovascular disease (CVD) in a large cohort of patients with heterozygous …

Significance of lipoprotein (a) levels in familial hypercholesterolemia and coronary artery disease

S Li, NQ Wu, CG Zhu, Y Zhang, YL Guo, Y Gao, XL Li… - Atherosclerosis, 2017 - Elsevier
Background and aims Patients with familial hypercholesterolemia (FH) are often
characterized by premature coronary artery disease (CAD) with heterogeneity at onset. The …

Lipoprotein (a) is an independent risk factor for cardiovascular disease in heterozygous familial hypercholesterolemia

DT Holmes, BA Schick, KH Humphries… - Clinical …, 2005 - academic.oup.com
Background: The role of lipoprotein (a)[Lp (a)] as a predictor of cardiovascular disease
(CVD) in patients with heterozygous familial hypercholesterolemia (HFH) is unclear. We …

Ascertainment bias in the association between elevated lipoprotein (a) and familial hypercholesterolemia

M Trinder, ML DeCastro, H Azizi, L Cermakova… - Journal of the American …, 2020 - jacc.org
Background Lipoprotein (a) is an atherogenic low-density lipoprotein–like particle and
circulating levels are largely determined by genetics. Patients with familial …

Lipoprotein (a) as a cardiovascular risk factor: current status

BG Nordestgaard, MJ Chapman, K Ray… - European heart …, 2010 - academic.oup.com
Aims The aims of the study were, first, to critically evaluate lipoprotein (a)[Lp (a)] as a
cardiovascular risk factor and, second, to advise on screening for elevated plasma Lp (a), on …

Lipoprotein (a) in homozygous familial hypercholesterolemia

HG Kraft, A Lingenhel, FJ Raal… - … , and vascular biology, 2000 - Am Heart Assoc
Lipoprotein (a)[Lp (a)] is a quantitative genetic trait that in the general population is largely
controlled by 1 major locus—the locus for the apolipoprotein (a)[apo (a)] gene. Sibpair …

Phenotypic characterization of genetically lowered human lipoprotein (a) levels

CA Emdin, AV Khera, P Natarajan, D Klarin… - Journal of the American …, 2016 - jacc.org
Background: Genomic analyses have suggested that the LPA gene and its associated
plasma biomarker, lipoprotein (a)(Lp [a]), represent a causal risk factor for coronary heart …

Familial hypercholesterolemia and elevated lipoprotein (a): double heritable risk and new therapeutic opportunities

A Vuorio, GF Watts, WJ Schneider… - Journal of internal …, 2020 - Wiley Online Library
There is compelling evidence that the elevated plasma lipoprotein (a)[Lp (a)] levels increase
the risk of atherosclerotic cardiovascular disease (ASCVD) in the general population. Like …

Prevalence of lipoprotein (a)[Lp (a)] excess in coronary artery disease

J Genest Jr, JL Jenner, JR McNamara… - The American journal of …, 1991 - Elsevier
Abstract Lipoprotein (a)[Lp (a)] is composed of 1 low-density lipoprotein (LDL) particle, to
which 1 molecule of apolipoprotein (a) is covalently linked. Elevated levels of Lp (a) have …

Long term statin treatment reduces lipoprotein (a) concentrations in heterozygous familial hypercholesterolaemia

S Van Wissen, TJ Smilde, MD Trip, T de Boo… - Heart, 2003 - heart.bmj.com
Background: Raised plasma lipoprotein (a)(Lp (a)) is associated with increased risk of
cardiovascular disease. It is unknown whether increased Lp (a) is an additional risk factor for …