Mechanisms and functions of p38 MAPK signalling

A Cuadrado, AR Nebreda - Biochemical journal, 2010 - portlandpress.com
The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to
interpret a wide range of external signals and respond appropriately by generating a …

p38MAPK: stress responses from molecular mechanisms to therapeutics

LR Coulthard, DE White, DL Jones… - Trends in molecular …, 2009 - cell.com
The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …

[HTML][HTML] Molecular determinants that mediate selective activation of p38 MAP kinase isoforms

H Enslen, DM Brancho, RJ Davis - The EMBO journal, 2000 - embopress.org
The p38 mitogen-activated protein kinase (MAPK) group is represented by four isoforms in
mammals (p38α, p38β2, p38γ and p38δ). These p38 MAPK isoforms appear to mediate …

[HTML][HTML] p38 MAP-kinases pathway regulation, function and role in human diseases

A Cuenda, S Rousseau - Biochimica et Biophysica Acta (BBA)-Molecular …, 2007 - Elsevier
Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by a wide range
of cellular stresses as well as in response to inflammatory cytokines. There are four …

[HTML][HTML] An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

J Han, J Wu, J Silke - F1000Research, 2020 - ncbi.nlm.nih.gov
The p38 family is a highly evolutionarily conserved group of mitogen-activated protein
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …

In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance

Y Shi, M Gaestel - 2002 - degruyter.com
Mitogenactivated protein kinases (MAPKs) are evolutionarily conserved enzymes which
connect cellsurface receptors to regulatory targets within cells and convert receptor signals …

p38 MAPK signalling cascades: ancient roles and new functions

E Martín‐Blanco - Bioessays, 2000 - Wiley Online Library
Abstract p38 MAPKs are a conserved subfamily of MAPKs involved in the response to stress
found in eukaryotic cells from yeast to mammals. The recent isolation of genes coding for …

Activation and signaling of the p38 MAP kinase pathway

T Zarubin, J Han - Cell research, 2005 - nature.com
The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety
of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups …

Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system

K Takeda, H Ichijo - Genes to Cells, 2002 - Wiley Online Library
p38 mitogen‐activated protein kinases (MAPKs), together with extracellular signal‐regulated
kinases (ERKs) and c‐Jun N‐terminal kinases (JNKs), constitute the MAPK family. Multiple …

Atypical p38 signaling, activation, and implications for disease

JC Burton, W Antoniades, J Okalova, MM Roos… - International Journal of …, 2021 - mdpi.com
The mitogen-activated protein kinase (MAPK) p38 is an essential family of kinases,
regulating responses to environmental stress and inflammation. There is an ever-increasing …