Arginase exists in two isoforms, the hepatic (arginase I) and extrahepatic types (arginase II).
Arginase I is markedly induced in rat peritoneal macrophages and rat tissues in vivo by …

Activated macrophages avidly consume arginine via the action of inducible nitric oxide
synthase (iNOS) and/or arginase. In contrast to our knowledge regarding macrophage iNOS …

Experiments were performed to identify arginase isoforms expressed in primary and
transformed rodent macrophages and to determine the molecular mechanisms for the …

Nitric oxide is synthesized by nitric-oxide synthase from arginine, a common substrate of
arginase. Rat peritoneal macrophages were cultured in the presence of bacterial …

Macrophages can express two arginase isoforms with distinct subcellular localization
(cytosolic AI and mitochondrial AII). These isoforms are products of different genes and are …

Previous studies have shown high arginase activity at inflammatory sites. Arginase convertsl-
arginine tol-ornithine, sharing a common substrate with nitric oxide synthase. It exists as two …

As arginase by limiting nitric oxide (NO) synthesis may play a role in airway
hyperresponsiveness and glucocorticoids are known to induce the expression of arginase I …

Nitric oxide (NO) is synthesized from arginine by nitric-oxide synthase (NOS), and citrulline
that is generated can be recycled to arginine by argininosuccinate synthase (AS) and …

The primary metabolic fates of L-arginine are conversion to L-citrulline by nitric oxide
synthase (NOS) and to L-ornithine by arginase. In the lung, arginine utilization is increased …

Arginase, which catalyzes the conversion of arginine to urea and ornithine, and consists of a
liver-type (arginase I) and a non-hepatic type (arginase II). Arginine is also used for the …