Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway

ML Lin, YC Lu, JG Chung, YC Li, SG Wang… - Cancer letters, 2010 - Elsevier
Aloe-emodin (AE), a natural, biologically active compound from the rhizome of Rheum
palmatum, has been shown to induce apoptosis in several cancer cell lines in vitro …

Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells

TH Chiu, WW Lai, TC Hsia, JS Yang, TY Lai… - Anticancer …, 2009 - ar.iiarjournals.org
Aloe-emodin, one of the anthraquinones, has been shown to have anticancer activity in
different kinds of human cancer cell lines. Therefore, the purpose of this study was to …

Aloe emodin‐induced apoptosis in t‐HSC/Cl‐6 cells involves a mitochondria‐mediated pathway

LH Lian, EJ Park, HS Piao, YZ Zhao… - Basic & clinical …, 2005 - Wiley Online Library
The aim of our study was to clarify the apoptosis pathway induced by aloe emodin, an
hydroxyanthraquinone present in aloe vera leaves, in rat hepatic stellate cells transformed …

Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma

HZ Lee, SL Hsu, MC Liu, CH Wu - European journal of pharmacology, 2001 - Elsevier
Aloe-emodin (1, 8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is an active component from
the root and rhizome of Rheum palmatum. The study investigated the effects and …

Signaling pathway for aloe‐emodin‐induced apoptosis in human H460 lung nonsmall carcinoma cell

FT Yeh, CH Wu, HZ Lee - International journal of cancer, 2003 - Wiley Online Library
Abstract Aloe‐emodin (1, 8‐dihydroxy‐3‐(hydroxymethyl)‐anthraquinone) is an active
component from the root and rhizome of Rheum palmatum that has been reported to exhibit …

Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human U87 malignant glioma cells by aloe emodin

S Ismail, K Haris, ARI Abdul Ghani… - Journal of Asian …, 2013 - Taylor & Francis
Aloe emodin, one of the active compounds found in Aloe vera leaves, plays an important
role in the regulation of cell growth and death. It has been reported to promote the anti …

Aloe emodin induces G2/M cell cycle arrest and apoptosis via activation of caspase-6 in human colon cancer cells

P Suboj, S Babykutty, P Srinivas, S Gopala - Pharmacology, 2012 - karger.com
Aloe emodin (AE), a natural anthraquinone, is reported to have antiproliferative activity in
various cancer cell lines. In this study, we analyzed the molecular mechanisms involved in …

[HTML][HTML] Induction of apoptosis in HepaRG cell line by aloe-emodin through generation of reactive oxygen species and the mitochondrial pathway

X Dong, J Fu, X Yin, C Qu, C Yang, H He… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: Aloe-emodin (1, 8-dihydroxy-3-hydroxymethyl-anthraquinone), an
anthraquinone active compounds, is isolated from some traditional medicinal plants such as …

[HTML][HTML] Aloe-emodin, an anthraquinone, in vitro inhibits proliferation and induces apoptosis in human colon carcinoma cells

KY Lin, YH Uen - Oncology letters, 2010 - spandidos-publications.com
The present study aimed to investigate the anticancer effect of aloe-emodin, an
anthraquinone compound present in the leaves of Aloe vera, on two human colon …

Aloe-emodin-induced apoptosis in human gastric carcinoma cells

SH Chen, KY Lin, CC Chang, CL Fang… - Food and chemical …, 2007 - Elsevier
The purpose of this study was to investigate the anticancer effect of aloe-emodin, an
anthraquinone compound present in the leaves of Aloe vera, on two distinct human gastric …