Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate
Chronic Trypanosoma cruzi infections are typically lifelong, with small numbers of parasites
surviving in restricted tissue sites, which include the gastrointestinal tract. There is …
surviving in restricted tissue sites, which include the gastrointestinal tract. There is …
[HTML][HTML] Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection
Investigations into intracellular replication and differentiation of Trypanosoma cruzi within
the mammalian host have been restricted by limitations in our ability to detect parasitized …
the mammalian host have been restricted by limitations in our ability to detect parasitized …
Incomplete recruitment of protective T cells is associated with trypanosoma cruzi persistence in the mouse colon
Trypanosoma cruzi is the etiological agent of Chagas disease. Following T cell-mediated
suppression of acute-phase infection, this intracellular eukaryotic pathogen persists long …
suppression of acute-phase infection, this intracellular eukaryotic pathogen persists long …
In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution
AI Ward, MD Lewis, AA Khan, CJ McCann… - Mbio, 2020 - Am Soc Microbiol
Infections with Trypanosoma cruzi are usually lifelong despite generating a strong adaptive
immune response. Identifying the sites of parasite persistence is therefore crucial to …
immune response. Identifying the sites of parasite persistence is therefore crucial to …
A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease
JM Bustamante, F Sanchez-Valdez… - Science translational …, 2020 - science.org
A major contributor to treatment failure in Chagas disease, caused by infection with the
protozoan parasite Trypanosoma cruzi, is that current treatment regimens do not address the …
protozoan parasite Trypanosoma cruzi, is that current treatment regimens do not address the …
[HTML][HTML] Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice
S Jayawardhana, AI Ward, AF Francisco… - PLoS …, 2023 - journals.plos.org
Benznidazole is the front-line drug used to treat infections with Trypanosoma cruzi, the
causative agent of Chagas disease. However, for reasons that are unknown, treatment …
causative agent of Chagas disease. However, for reasons that are unknown, treatment …
[HTML][HTML] Trypanosoma cruzi amastigote transcriptome analysis reveals heterogenous populations with replicating and dormant parasites
H Desale, C Herrera, E Dumonteil - Microbes and Infection, 2024 - Elsevier
Trypanosoma cruzi is a protozoan parasite causing Chagas disease, with a complex life
cycle involving different stages in insect vectors and mammalian hosts. Amastigotes are an …
cycle involving different stages in insect vectors and mammalian hosts. Amastigotes are an …
Transcriptome profile of Trypanosoma cruzi-infected cells: simultaneous up- and down-regulation of proliferation inhibitors and promoters
T Shigihara, M Hashimoto, N Shindo, T Aoki - Parasitology research, 2008 - Springer
As Trypanosoma cruzi, the etiological agent of Chagas disease, multiplies in the cytoplasm
of nucleated host cells, infection with this parasite is highly likely to affect host cells. We …
of nucleated host cells, infection with this parasite is highly likely to affect host cells. We …
Putting infection dynamics at the heart of Chagas disease
MD Lewis, JM Kelly - Trends in parasitology, 2016 - cell.com
In chronic Trypanosoma cruzi infections, parasite burden is controlled by effective, but
nonsterilising immune responses. Infected cells are difficult to detect because they are …
nonsterilising immune responses. Infected cells are difficult to detect because they are …
Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy
Host and parasite diversity are suspected to be key factors in Chagas disease pathogenesis.
Experimental investigation of underlying mechanisms is hampered by a lack of tools to …
Experimental investigation of underlying mechanisms is hampered by a lack of tools to …