Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers
ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in
cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation …
cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation …
[HTML][HTML] Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription
S Blümli, N Wiechens, MY Wu, V Singh, M Gierlinski… - Cell reports, 2021 - cell.com
The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor
suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at …
suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at …
ARID1A loss in cancer: towards a mechanistic understanding
R Mathur - Pharmacology & therapeutics, 2018 - Elsevier
Genes encoding subunits of SWI/SNF chromatin remodeling complexes are collectively
mutated in 20% of all human cancers. ARID1A is the SWI/SNF subunit gene that is most …
mutated in 20% of all human cancers. ARID1A is the SWI/SNF subunit gene that is most …
ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice
Genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are
collectively mutated in∼ 20% of all human cancers,. Although ARID1A is the most frequent …
collectively mutated in∼ 20% of all human cancers,. Although ARID1A is the most frequent …
The tumor suppressor ARID1A controls global transcription via pausing of RNA polymerase II
AT-rich interactive domain-containing proteins 1A and 1B (ARID1A and ARID1B) are
mutually exclusive subunits of the chromatin remodeler SWI/SNF. ARID1A is the most …
mutually exclusive subunits of the chromatin remodeler SWI/SNF. ARID1A is the most …
ARID1A Mutations in Cancer: Another Epigenetic Tumor Suppressor?
JN Wu, CWM Roberts - Cancer discovery, 2013 - AACR
Although disordered chromatin organization has long been recognized as a feature of
cancer, the molecular underpinnings of chromatin structure, epigenetic regulation, and their …
cancer, the molecular underpinnings of chromatin structure, epigenetic regulation, and their …
ARID1B is a specific vulnerability in ARID1A-mutant cancers
Recent studies have revealed that ARID1A, encoding AT-rich interactive domain 1A (SWI-
like), is frequently mutated across a variety of human cancers and also has bona fide tumor …
like), is frequently mutated across a variety of human cancers and also has bona fide tumor …
Reduced expression of the chromatin remodeling gene ARID1A enhances gastric cancer cell migration and invasion via downregulation of E-cadherin transcription
HB Yan, XF Wang, Q Zhang, ZQ Tang, YH Jiang… - …, 2014 - academic.oup.com
The chromatin remodeling gene AT-rich interactive domain-containing protein 1A (ARID1A)
encodes the protein BAF250a, a subunit of human SWI/SNF-related complexes. Recent …
encodes the protein BAF250a, a subunit of human SWI/SNF-related complexes. Recent …
[HTML][HTML] Arid1a has context-dependent oncogenic and tumor suppressor functions in liver cancer
Summary ARID1A, an SWI/SNF chromatin-remodeling gene, is commonly mutated in cancer
and hypothesized to be tumor suppressive. In some hepatocellular carcinoma patients …
and hypothesized to be tumor suppressive. In some hepatocellular carcinoma patients …
ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer
T Moreno, B Monterde, L González-Silva… - Oncogene, 2021 - nature.com
The survival rate in lung cancer remains stubbornly low and there is an urgent need for the
identification of new therapeutic targets. In the last decade, several members of the SWI/SNF …
identification of new therapeutic targets. In the last decade, several members of the SWI/SNF …