Intracellular recordings of membrane potential in vitro have defined fundamental properties
of synaptic communication. Much less is known about the properties of synaptic connectivity …

Synaptic interactions between nearby excitatory and inhibitory neurons in the neocortex are
thought to play fundamental roles in sensory processing. Here, we have combined …

Background Proper function of the mammalian brain relies on the establishment of highly
specific synaptic connections among billions of neurons. To understand how complex neural …

The cellular and synaptic mechanisms driving cell-type-specific function during various
cortical network activities and behaviors are poorly understood. Here, we targeted whole …

The organization of synaptic connectivity within a neuronal circuit is a prime determinant of
circuit function. We performed a comprehensive fine-scale circuit mapping of hippocampal …

Key points Using functional mapping assays, we conducted a quantitative assessment of
both excitatory and inhibitory synaptic laminar connections to excitatory neurons in layers …

Synaptic excitation mediates a broad spectrum of structural changes in neural circuits across
the brain. Here, we examine the morphologies, wiring, and architectures of single synapses …

In the brain, synapses are specialized junctions between neurons, determining the strength
and spread of neuronal signaling. The number of synapses is tightly regulated during …

Depolarization of the neuronal soma augments synaptic output onto postsynaptic neurons
via long-range, axonal cable properties. Here, we report that the range of this somatic …

Little is known about the properties of monosynaptic connections between identified
neurons in vivo. We made multiple (two to four) two-photon targeted whole-cell recordings …