Stem cell regulation by local signals is intensely studied, but less is known about the effects
of hormonal signals on stem cells. In Drosophila, the primary steroid twenty …

Steroid hormones are known systemic regulators of multiple normal and cancerous tissues;
however, whether or how they impact the fate and function of adult stem cells is unclear. In …

Drosophila adult females but not males contain high levels of the steroid hormone
ecdysone, however, the roles played by steroid signaling during Drosophila gametogenesis …

Stem cell niche is regulated by intrinsic and extrinsic factors. In the Drosophila testis, cyst
stem cells (CySCs) support the differentiation of germline stem cells (GSCs). However, the …

The ability of adult stem cells to maintain their undifferentiated state depends upon
residence in their niche. While simple models of a single self-renewal signal are attractive …

Previously, it has been shown that in Drosophila steroid hormones are required for
progression of oogenesis during late stages of egg maturation. Here, we show that …

In metazoans, tissue maintenance and regeneration depend on adult stem cells, which are
characterized by their ability to self-renew and generate differentiating progeny in response …

Male reproductive glands like the mammalian prostate and the paired Drosophila
melanogaster accessory glands secrete seminal fluid components that enhance fecundity. In …

Stem cells reside within specialized microenvironments, or niches, that control many aspects
of stem cell behavior. Somatic hub cells in the Drosophila testis regulate the behavior of cyst …

The germline stem cells (GSCs) are critical for gametogenesis throughout the adult life. Stem
cell identity is maintained by local signals from a specialized microenvironment called the …