Leptin receptor gene mutations are a very rare cause of severe early-onset obesity. They are
also associated with lack of pubertal development and intense hyperphagia. Presented here …

Congenital deficiency of the leptin receptor is a very rare cause of severe early-onset
obesity. To date, only 9 families have been reported in the literature to have mutations in the …

Congenital leptin deficiency is a rare recessively inherited condition due to homozygous
mutations in the LEP gene. To date, only nine mutations have been identified in the LEP …

Congenital leptin deficiency is a rare, but treatable, cause of severe early-onset obesity. To
date, two United Kingdom families of Pakistani origin carrying a frameshift/premature stop …

Congenital leptin deficiency is a rare recessive genetic disorder resulting in severe
hyperphagia and early onset obesity. It is caused by mutations in the LEP gene encoding …

Context: Congenital leptin deficiency is a very rare cause of severe early-onset obesity. We
recently characterized a mutation in the leptin gene (p. D100Y), which was associated with …

Background Early childhood obesity is a public health problem worldwide. It affects different
aspects of physical and mental child's health. Identifying the etiologies, especially treatable …

Obesity is a chronic disorder that is believed to be due to numerous interacting genetic and
non-genetic factors as typically found in multifactorial diseases [Walley et al., 2009]. The …

Monogenic obesity, caused by mutations in one of the genes involved in the control of
hunger and satiety, is a rare cause of early onset obesity (EOO). The most common of the …

Background: Congenital leptin deficiency is a rare human genetic condition clinically
characterized by hyperphagia and acute weight gain usually during the first postnatal year …