The contribution and therapeutic potential of epigenetic modifications in Alzheimer's disease

IC Wood - Frontiers in neuroscience, 2018 - frontiersin.org
Alzheimer's disease is a progressive neurodegenerative disorder, affecting 50 million
people worldwide, for which there is no cure, or effective treatment. Individuals suffering from …

The epigenetics of Alzheimer's disease: factors and therapeutic implications

X Liu, B Jiao, L Shen - Frontiers in genetics, 2018 - frontiersin.org
Alzheimer's disease (AD) is a well-known neurodegenerative disorder that imposes a great
burden on the world. The mechanisms of AD are not yet fully understood. Current insight into …

[HTML][HTML] Epigenetic modification and its role in Alzheimer's disease

YP Zhu, Y Feng, T Liu, YC Wu - Integrative Medicine International, 2015 - karger.com
Alzheimer's disease (AD) is the most common neurodegenerative disease, and its
mechanisms have not been clearly elucidated. A large percentage (more than 95%) of …

Epigenetics: Recent advances and its role in the treatment of Alzheimer's disease

X Xiao, X Liu, B Jiao - Frontiers in Neurology, 2020 - frontiersin.org
Objective: This review summarizes recent findings on the epigenetics of Alzheimer's disease
(AD) and provides therapeutic strategies for AD. Methods: We searched the following …

Epigenetic processes in Alzheimer's disease

I Castanho, K Lunnon - Chromatin Signaling and Neurological Disorders, 2019 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
memory loss and cognitive decline, which are consequences of chronic progressive …

Into the fourth dimension: dysregulation of genome architecture in aging and Alzheimer's disease

W Winick-Ng, RJ Rylett - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
synapse dysfunction and cognitive impairment. Understanding the development and …

Epigenetic mechanisms in Alzheimer's disease

M Daniilidou, M Koutroumani… - Current medicinal …, 2011 - ingentaconnect.com
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders affecting
elderly people (over 65 years old). Only a small percentage (less than 5%) of the disease is …

Epigenetic mechanisms in Alzheimer's disease: implications for pathogenesis and therapy

J Wang, JT Yu, MS Tan, T Jiang, L Tan - Ageing research reviews, 2013 - Elsevier
The vast majority of Alzheimer's disease (AD) are late-onset forms (LOAD) likely due to the
interplay of environmental influences and individual genetic susceptibility. Epigenetic …

The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism

HU Klein, DA Bennett, PL De Jager - Acta neuropathologica, 2016 - Springer
The advent of new technologies and analytic approaches is beginning to provide an
unprecedented look at features of the human genome that affect RNA expression. These …

Epigenetic Changes in Alzheimer's Disease: DNA Methylation and Histone Modification

LM De Plano, A Saitta, S Oddo, A Caccamo - Cells, 2024 - mdpi.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
progressive cognitive decline and memory loss, imposing a significant burden on affected …