Alzheimer's disease (AD) is a hereditary and sporadic neurodegenerative illness defined by
the gradual and cumulative loss of neurons in specific brain areas. The processes that …

Alzheimer's disease (AD) is a neurodegenerative disease, caused by poorly known
pathogenic mechanisms and aggravated by delayed therapeutic intervention, that still lacks …

Mitochondrial dysregulation is pivotal in Alzheimer's disease (AD) pathogenesis. Calcium
governs vital mitochondrial processes impacting energy conversion, oxidative stress, and …

Abstract Alzheimer's disease (AD), the most common cause of dementia, affects millions of
people worldwide. Suggested mechanisms of neurotoxicity in AD include impaired calcium …

Mitochondria absorb calcium (Ca2+) at the expense of the electrochemical gradient
generated during respiration. The influx of Ca2+ into the mitochondrial matrix helps maintain …

Calcium signaling is essential for neuronal function, and its dysregulation has been
implicated across neurodegenerative diseases, including Alzheimer's disease (AD). A close …

Functional mitochondria are vital to accomplish their key role in the cell, by maintaining the
energy metabolism, buffering of the Ca 2+ signal and directing the cell death mechanism …

Mitochondria represent the main powerhouse of the cell, producing the majority of ATP
molecules needed for all the cell processes. In particular, excitable cells, such as neurons …

Age is the main risk factor for the onset of neurodegenerative diseases. A decline of
mitochondrial function has been observed in several age-dependent neurodegenerative …

Perturbed neuronal calcium homeostasis is a prominent feature in Alzheimer's disease (AD).
Mitochondria accumulate calcium ions (Ca2+) for cellular bioenergetic metabolism and …