[HTML][HTML] Combined therapy with atorvastatin and atorvastatin-pretreated mesenchymal stem cells enhances cardiac performance after acute myocardial infarction by …

XQ Tian, YJ Yang, Q Li, J Xu, PS Huang… - American Journal of …, 2019 - ncbi.nlm.nih.gov
Abstract The SDF-1/CXCR4 signaling plays a critical role in the trafficking of mesenchymal
stem cells (MSCs) to the sites of tissue damage. Our recent study demonstrated that …

[HTML][HTML] Intravenous administration of atorvastatin-pretreated mesenchymal stem cells improves cardiac performance after acute myocardial infarction: role of CXCR4

N Li, YJ Yang, HY Qian, Q Li, Q Zhang… - American journal of …, 2015 - ncbi.nlm.nih.gov
Background: The interaction between stromal cell-derived factor 1 (SDF-1) and its receptor
CXC chemokine receptor 4 (CXCR4) plays an important role in mesenchymal stem cells …

Optimization of timing and times for administration of atorvastatin-pretreated mesenchymal stem cells in a preclinical model of acute myocardial infarction

J Xu, YY Xiong, Q Li, MJ Hu, PS Huang… - Stem cells …, 2019 - academic.oup.com
Our previous studies showed that the combination of atorvastatin (ATV) and single injection
of ATV-pretreated mesenchymal stem cells (MSCs)(ATV-MSCs) at 1 week post-acute …

Marrow-derived MSCs and atorvastatin improve cardiac function in rat model of AMI

A Wang, F Shen, Y Liang, J Wang - International journal of cardiology, 2011 - Elsevier
OBJECTIVE: Both atorvastatin and cell-based therapy were reportedly beneficial to
ventricular function after acute myocardial infarction (AMI). In this study, we sought to study …

[HTML][HTML] Atorvastatin improves microenvironment to enhance the beneficial effects of BMSCs therapy in a rabbit model of acute myocardial infarction

Z Qu, H Xu, Y Tian, X Jiang - Cellular Physiology and Biochemistry, 2013 - karger.com
Background/Aims: To investigate the beneficial effects of atorvastatin added to the cell
therapy with bone marrow-derived mesenchymal stromal cells (BMSCs) in a rabbit model of …

Atorvastatin treatment of rats with ischemia-reperfusion injury improves adipose-derived mesenchymal stem cell migration and survival via the SDF-1α/CXCR-4 axis

A Cai, R Qiu, L Li, D Zheng, Y Dong, D Yu, Y Huang… - PloS one, 2013 - journals.plos.org
Background Adipose-derived mesenchymal stem cells (ASCs) transplantation is a promising
approach for myocardium repair. Promotion of ASCs migration and survival is the key for …

Atorvastatin treatment improves effects of implanted mesenchymal stem cells: meta-analysis of animal models with acute myocardial infarction

G Dai, Q Xu, R Luo, J Gao, H Chen, Y Deng… - BMC Cardiovascular …, 2015 - Springer
Background Previous studies reported that Atorvastatin (ATOR) can improve the efficacy of
Mesenchymal stem cells (MSCs) transplantation after acute myocardial infarction (AMI) …

Rosuvastatin enhances the therapeutic efficacy of adipose-derived mesenchymal stem cells for myocardial infarction via PI3K/Akt and MEK/ERK pathways

Z Zhang, S Li, M Cui, X Gao, D Sun, X Qin… - Basic Research in …, 2013 - Springer
The poor viability of transplanted stem cells hampers their therapeutic efficacy for treatment
of myocardial infarction. The aim of this study was to investigate whether rosuvastatin …

Combined therapy with simvastatin and bone marrow–derived mesenchymal stem cells increases benefits in infarcted swine hearts

YJ Yang, HY Qian, J Huang, JJ Li, RL Gao… - … , and vascular biology, 2009 - Am Heart Assoc
Objective—Widespread death of implanted cells hampers stem cell therapy for acute
myocardial infarction (AMI). Based on the pleiotropic beneficial effects of statins, we …

Rosuvastatin treatment activates JAK-STAT pathway and increases efficacy of allogeneic mesenchymal stem cell transplantation in infarcted hearts

H Xu, YJ Yang, HY Qian, YD Tang, H Wang… - Circulation …, 2011 - jstage.jst.go.jp
Background: Widespread death of implanted cells hampers the development of stem cell
therapy for acute myocardial infarction (AMI). Our previous studies indicated that statins can …