Implications of genome wide association studies for addiction: are our a priori assumptions all wrong?
Substantial genetic contributions to addiction vulnerability are supported by data from twin
studies, linkage studies, candidate gene association studies and, more recently, Genome …
studies, linkage studies, candidate gene association studies and, more recently, Genome …
Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction
Background Classical genetic studies provide strong evidence for heritable contributions to
susceptibility to developing dependence on addictive substances. Candidate gene and …
susceptibility to developing dependence on addictive substances. Candidate gene and …
Molecular genetics of addiction and related heritable phenotypes: genome‐wide association approaches identify “connectivity constellation” and drug target genes …
Genome‐wide association (GWA) can elucidate molecular genetic bases for human
individual differences in complex phenotypes that include vulnerability to addiction. Here …
individual differences in complex phenotypes that include vulnerability to addiction. Here …
“Higher order” addiction molecular genetics: convergent data from genome-wide association in humans and mice
GR Uhl, T Drgon, C Johnson, OO Fatusin… - Biochemical …, 2008 - Elsevier
Family, adoption and twin data each support substantial heritability for addictions. Most of
this heritable influence is not substance-specific. The overlapping genetic vulnerability for …
this heritable influence is not substance-specific. The overlapping genetic vulnerability for …
Human genetics of addiction: new insights and future directions
DB Hancock, CA Markunas, LJ Bierut… - Current psychiatry …, 2018 - Springer
Abstract Purpose of Review With the advent of the genome-wide association study (GWAS),
our understanding of the genetics of addiction has made significant strides forward. Here …
our understanding of the genetics of addiction has made significant strides forward. Here …
The genetics of addiction—a translational perspective
Addictions are serious and common psychiatric disorders, and are among the leading
contributors to preventable death. This selective review outlines and highlights the need for …
contributors to preventable death. This selective review outlines and highlights the need for …
Will we ever find the genes for addiction?
PR Buckland - Addiction, 2008 - Wiley Online Library
Aim To assess the likelihood of finding genes which predispose to addiction and to present
this information in a form accessible to the general readership of Addiction. Methods Review …
this information in a form accessible to the general readership of Addiction. Methods Review …
Genome wide association for addiction: replicated results and comparisons of two analytic approaches
Background Vulnerabilities to dependence on addictive substances are substantially
heritable complex disorders whose underlying genetic architecture is likely to be polygenic …
heritable complex disorders whose underlying genetic architecture is likely to be polygenic …
Molecular genetic underpinnings of human substance abuse vulnerability: likely contributions to understanding addiction as a mnemonic process
GR Uhl - Neuropharmacology, 2004 - Elsevier
Classical genetic studies document strong complex genetic contributions to abuse of
multiple addictive substances. These genetic influences are more prominent in the later …
multiple addictive substances. These genetic influences are more prominent in the later …
Addiction genetics and pleiotropic effects of common haplotypes that make polygenic contributions to vulnerability to substance dependence
Abundant evidence from family, adoption, and twin studies point to large genetic
contributions to individual differences in vulnerability to develop dependence on one or …
contributions to individual differences in vulnerability to develop dependence on one or …