Implications of genome wide association studies for addiction: are our a priori assumptions all wrong?

FS Hall, J Drgonova, S Jain, GR Uhl - Pharmacology & therapeutics, 2013 - Elsevier
Substantial genetic contributions to addiction vulnerability are supported by data from twin
studies, linkage studies, candidate gene association studies and, more recently, Genome …

Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction

CY Li, WZ Zhou, PW Zhang, C Johnson, L Wei, GR Uhl - BMC genomics, 2011 - Springer
Background Classical genetic studies provide strong evidence for heritable contributions to
susceptibility to developing dependence on addictive substances. Candidate gene and …

Molecular genetics of addiction and related heritable phenotypes: genome‐wide association approaches identify “connectivity constellation” and drug target genes …

GR Uhl, T Drgon, C Johnson, CY Li… - Annals of the New …, 2008 - Wiley Online Library
Genome‐wide association (GWA) can elucidate molecular genetic bases for human
individual differences in complex phenotypes that include vulnerability to addiction. Here …

“Higher order” addiction molecular genetics: convergent data from genome-wide association in humans and mice

GR Uhl, T Drgon, C Johnson, OO Fatusin… - Biochemical …, 2008 - Elsevier
Family, adoption and twin data each support substantial heritability for addictions. Most of
this heritable influence is not substance-specific. The overlapping genetic vulnerability for …

Human genetics of addiction: new insights and future directions

DB Hancock, CA Markunas, LJ Bierut… - Current psychiatry …, 2018 - Springer
Abstract Purpose of Review With the advent of the genome-wide association study (GWAS),
our understanding of the genetics of addiction has made significant strides forward. Here …

The genetics of addiction—a translational perspective

A Agrawal, KJH Verweij, NA Gillespie, AC Heath… - Translational …, 2012 - nature.com
Addictions are serious and common psychiatric disorders, and are among the leading
contributors to preventable death. This selective review outlines and highlights the need for …

Will we ever find the genes for addiction?

PR Buckland - Addiction, 2008 - Wiley Online Library
Aim To assess the likelihood of finding genes which predispose to addiction and to present
this information in a form accessible to the general readership of Addiction. Methods Review …

Genome wide association for addiction: replicated results and comparisons of two analytic approaches

T Drgon, PW Zhang, C Johnson, D Walther, J Hess… - PloS one, 2010 - journals.plos.org
Background Vulnerabilities to dependence on addictive substances are substantially
heritable complex disorders whose underlying genetic architecture is likely to be polygenic …

Molecular genetic underpinnings of human substance abuse vulnerability: likely contributions to understanding addiction as a mnemonic process

GR Uhl - Neuropharmacology, 2004 - Elsevier
Classical genetic studies document strong complex genetic contributions to abuse of
multiple addictive substances. These genetic influences are more prominent in the later …

Addiction genetics and pleiotropic effects of common haplotypes that make polygenic contributions to vulnerability to substance dependence

GR Uhl, T Drgon, C Johnson, QR Liu - Journal of neurogenetics, 2009 - Taylor & Francis
Abundant evidence from family, adoption, and twin studies point to large genetic
contributions to individual differences in vulnerability to develop dependence on one or …