Hepatic stellate cells (HSC) orchestrate the deposition of extracellular matrix (ECM) and are
the primary effector of liver fibrosis. Several factors, including TGF-β1, PDGF and oxidative …

Hepatic stellate cells (HSCs) play a crucial role in liver fibrosis, which is a pathological
process characterized by extracellular matrix accumulation. NR4A2 is a nuclear receptor …

Hepatic fibrogenesis is characterized by activation of hepatic stellate cells (HSCs) and
accumulation of extracellular matrix (ECM). The impact of ECM on TGF-β-mediated …

Background & Aims Endoplasmic reticulum (ER) stress has been implicated in a variety of
diseases. Hepatic stellate cells (HSCs) contribute to the development of liver fibrosis …

Hepatic stellate cells (HSCs) are universally acknowledged to play a core role in the
pathogenesis of hepatic fibrosis. HSCs when activated are characterized by dramatic loss of …

Background and objectives Liver fibrosis (LF) occurs following chronic liver injuries.
Currently, there is no effective therapy for LF. Recently, we identified thioredoxin domain …

Non-alcoholic fatty liver disease (NAFLD) has become one of the most common diseases
and severe problems worldwide because of the global increase in obesity, dyslipidemia …

Aims: Hepatic fibrosis results from chronic liver injury and inflammatory responses. Sestrin 2
(Sesn2), an evolutionarily conserved antioxidant enzyme, reduces the severities of acute …

The lipid-storage hepatic stellate cells (HSC) play as pivotal role in liver fibrosis being able
to trans-differentiate into myofibroblasts in response to various pro-fibrogenic stimuli. In the …

Abstract Background Hepatic stellate cells (HSCs) are liver-resident myofibroblast
precursors responsible for the production of collagen and maintenance of the hepatic …