We have examined the free energy effects of 5‐methylation of cytosine on the B⟷ Z
conformational equilibrium in DNA. Free energy differences were calculated using the free …

In this paper, the finite difference nonlinear Poisson− Boltzmann (NLPB) equation is used to
calculate the electrostatic contribution to the B to Z transition of DNA using detailed …

The influence of high concentrations of Na+ or [Co (NH 3) 6] 3+ on the conformation of two
related DNA oligomers was investigated by circular dichroism spectropolarimetry (CD) …

Molecular-mechanical studies of the left-handed Z-DNA polymers have been carried out and
the results compared with similar calculations on B-DNA polymers. We have studied d …

We have carried out free energy perturbation calculations on DNA double-stranded
hexanucleotides. The sequence d (CGCGCG) 2 has been" mutated" into d (CGTGCG). d …

Abstract The B̄ to Ā transition of DNA in water-ethanol solutions has been studied by
circular dichroism. The transition is reversible and co-operative and occurs within a narrow …

Conformation and conformational transitions of DNA molecules in solution cannot be
studied by direct structural methods. When indirect methods such as optical, thermodynamic …

High concentrations of Na+ or [Co (NH3) 6] 3+ can induce the B to Z conformational
transition in alternating (dC-dG) oligo and polynucleotides. The use of short DNA oligomers …

A method for calculating the free-energy difference between two dissimilar conformational
states of a nucleic acid is proposed. The procedure is especially suited for computer …

The likelihood that a given DNA sequence will adopt the Z conformation in negatively
supercoiled DNA depends on the energy difference between the B form and the Z form for …