Effects of maternal smoking on the placental expression of genes related to angiogenesis and apoptosis during the first trimester

A Kawashima, K Koide, W Ventura, K Hori… - PloS one, 2014 - journals.plos.org
Objective Maternal cigarette smoking is reportedly associated with miscarriage, fetal growth
restriction and placental abruption, and is paradoxically associated with a decreased risk of …

Decreased activation of placental mTOR family members is associated with the induction of intrauterine growth restriction by secondhand smoke in the mouse

C Mejia, J Lewis, C Jordan, J Mejia, C Ogden… - Cell and Tissue …, 2017 - Springer
Cigarette smoke is known to be a risk for the development of intrauterine growth restriction
(IUGR). Our objective was to assess the effects of secondhand smoke (SHS) during …

Evidence of altered brain regulatory gene expression in tobacco-exposed fetuses

HM Salihu, A Paothong, R Das, LM King… - Journal of Perinatal …, 2017 - degruyter.com
Aim: We sought to determine the association between prenatal smoking status and
expression of fetal brain regulatory genes. Methods: At delivery, we collected information …

Effect of maternal tobacco smoke exposure on the placental transcriptome

H Bruchova, A Vasikova, M Merkerova, A Milcova… - Placenta, 2010 - Elsevier
Smoking in pregnancy increases a woman's risk of preterm delivery resulting in serious
neonatal health problems and chronic lifelong disabilities for the children (eg, mental …

[HTML][HTML] Maternal smoke exposure decreases mesenchymal proliferation and modulates Rho-GTPase-dependent actin cytoskeletal signaling in fetal lungs

U Unachukwu, J Trischler, M Goldklang, R Xiao… - The FASEB …, 2017 - ncbi.nlm.nih.gov
The present study tested the hypothesis that maternal smoke exposure results in fetal lung
growth retardation due to dysregulation in various signaling pathways, including the Wnt …

Maternal exposures to cigarette smoke, alcohol, and street drugs and neural tube defect occurrence in offspring

L Suarez, M Felkner, JD Brender, M Canfield… - Maternal and child …, 2008 - Springer
Objectives Cigarettes, alcoholic beverages, and street drugs contain substances potentially
toxic to the developing embryo. We investigated whether maternal cigarette smoking …

Nicotine‐induced embryonic malformations mediated by apoptosis from increasing intracellular calcium and oxidative stress

Z Zhao, EA Reece - Birth Defects Research Part B …, 2005 - Wiley Online Library
BACKGROUND: Tobacco smoking by women during pregnancy increases the risk of
congenital birth defects in the infants. Among the smoke products, nicotine is believed to be …

miR‐322 treatment rescues cell apoptosis and neural tube defect formation through silencing NADPH oxidase 4

Y Liu, H Gu, T Huang, X Wei, W Ma… - CNS neuroscience & …, 2020 - Wiley Online Library
Aims Failure of neural tube closure resulting from excessive apoptosis leads to neural tube
defects (NTDs). NADPH oxidase 4 (NOX4) is a critical mediator of cell growth and death, yet …

A novel mutation in the gene encoding noggin is not causative in human neural tube defects

KA Bauer, TM George, DS Enterline… - Journal of …, 2002 - Taylor & Francis
Neural tube defects (NTD) are a common birth defect, with both genetic and environmental
contributions to their etiology. In mouse, null mutations in Noggin result in fully-penetrant …

Maternal smoking during pregnancy and neural tube defects in offspring: a meta-analysis

M Wang, ZP Wang, R Gong, ZT Zhao - Child's Nervous System, 2014 - Springer
Purpose This study aims to examine the association between maternal smoking during
pregnancy and neural tube defects (NTDs) in offspring. Methods We retrieved published …