Background: Sickle cell disease causes significant morbidity and mortality and affects the
economic and healthcare status of many countries. Yet historically, the disease has not had …

Sickle cell disease (SCD) afflicts millions of people worldwide but is referred to as an orphan
disease in the United States. Over the past several decades, there has been an increasing …

In the United States, sickle cell disease affects approximately 1 in 350 African-American
newborn infants each year, and approximately 72,000 individuals total. Sickle cell disease is …

Over 70,000 people live with sickle cell disease in the United States and multitudes world
wide. About 2000 afflicted babies are born in this country each year. In African countries …

Sickle cell disease afflicts millions of people worldwide and approximately 100,000
Americans. Complications are myriad and arise as a result of complex pathological …

Sickle cell disease is enormously variable in its expression and outcome. In addition to this
intrinsic variability are the problems of symptomatic selection biasing observations towards …

This large paperback book is a remarkable study of some 1500 sickle cell patients seen by
the author personally in Korle Bu Hospital, Accra, between 1965 and 1977. As such it must …

The familial pattern of recurring pain and early death seen so often among those affected by
sickle cell disease has been long recognized within African cultures, though its first clear …

Tremendous progress has been made in the care of individuals with sickle cell over the past
several decades. Major successes have been comprehensive infection prophylaxis …

Sickle cell anemia occurs in individuals who are homozygous for a single nucleotide
substitution in codon 6 of the beta-globin gene. This single mutation leads to the formation of …