Cryptococcus neoformans is a ubiquitous fungus that can cause life-threatening infections
during immunosuppressive states such as AIDS and after bone marrow transplantation. In …

CD40 signaling has been implicated in various pathogenic processes such as chronic
inflammatory disease, graft-versus-host disease, autoimmune disease and cancer. We …

To clear a Cryptosporidium parvum infection, mice need CD4+ T cells, major
histocompatibility complex class II, and an intact CD40-CD154 signaling pathway. CD40 is …

This study explored the role of CD40/CD40 ligand (CD40L) in the induction of a
lymphoproliferative response and killing of Cryptococcus neoformans in vitro. In our …

The brain represents a significant barrier for protective immune responses in both infectious
disease and cancer. We have recently demonstrated that immunotherapy with anti-CD40 …

Despite appropriate antifungal treatment, the management of cryptococcal disease remains
challenging, especially in immunocompromised patients, such as human immunodeficiency …

Cryptococcus neoformans is a ubiquitous fungus that can cause lifethreatening infections
during immunosuppressive states such as acquired immunodeficiency syndrome (AIDS) …

Cryptococcus neoformans is an encapsulated fungus that is a major cause of meningitis in
patients with AIDS. In immunocompetent mice, administration of IgG1 mAb protects against …

Cryptococcus neoformans is a frequent cause of meningoencephalitis in
immunosuppressed individuals. To better understand the mechanisms of a protective …

Cryptococcosis is an hematogenously disseminated meningoencephalitis during which the
relationship between the disease severity and the immune response remains unclear. We …