Diesel Exhaust (DE)–Induced Cytokine Expression in Human Bronchial Epithelial Cells: A Study with a New Cell Exposure System to Freshly Generated DE In Vitro

S Abe, H Takizawa, I Sugawara… - American Journal of …, 2000 - atsjournals.org
We devised a new in vitro cell exposure system to freshly generated diesel exhaust (DE),
different from conventional in vitro culture systems, to examine the effects of DE on human …

Effects of diesel exhaust on murine alveolar macrophages and a macrophage cell line

Y Saito, A Azuma, S Kudo, H Takizawa… - Experimental lung …, 2002 - Taylor & Francis
To investigatethe effects of diesel exhaust particles (DEP) and mycobacterial infection on
macrophages, we examined protein and mRNA expression levels of various cytokines …

Long-term inhalation of diesel exhaust affects cytokine expression in murine lung tissues: comparison between low-and high-dose diesel exhaust exposure

Y Saito, A Azuma, S Kudo, H Takizawa… - Experimental lung …, 2002 - Taylor & Francis
The authors investigated the effect of diesel exhaust (DE) on cytokine expression in murine
lung tissues. BALB/c mice were exposed to DE for 1 month at different dose levels of DE …

Benzene-extracted components are important for the major activity of diesel exhaust particles: effect on interleukin-8 gene expression in human bronchial epithelial …

S Kawasaki, H Takizawa, K Takami… - American journal of …, 2001 - atsjournals.org
Epidemiologic and experimental studies suggest that diesel exhaust particles (DEPs) may
be related to increasing respiratory mortality and morbidity. We have shown that DEPs …

The Effect of Diesel Exhaust Particles on Cell Function and Release of Inflammatory Mediators from Human Bronchial Epithelial Cells In Vitro

H Bayram, JL Devalia, RJ Sapsford… - American journal of …, 1998 - atsjournals.org
Animal studies have reported that diesel exhaust particles (DEP), which constitute an
important fraction of particulate air pollution, lead to inflammation and/or damage of the …

Diesel exhaust particles induced release of interleukin 6 and 8 by (primed) human bronchial epithelial cells (BEAS 2B) in vitro

PA Steerenberg, JAJ Zonnenberg… - Experimental lung …, 1998 - Taylor & Francis
Several epidemiological studies have recently shown associations of increased premature
mortality rates with ambient paniculate air pollution. Diesel exhaust particles (DEP) may …

Diesel exhaust particles activate human bronchial epithelial cells to express inflammatory mediators in the airways: a review

H Takizawa, T Ohtoshi, S Kawasaki, S Abe… - …, 2000 - Wiley Online Library
Objective: Epidemiological as well as experimental studies suggest that particulate air
pollutants, including diesel exhaust particles (DEP), may play a role in the recent increase of …

Inhalation of diesel exhaust for three months affects major cytokine expression and induces bronchus-associated lymphoid tissue formation in murine lungs

K Hiramatsu, A Azuma, S Kudoh, M Desaki… - Experimental lung …, 2003 - Taylor & Francis
The authors investigated the effects of exposure to diesel exhaust (DE) on murine lung
tissues invivo. BALB/c and C57BL/6 mice were exposed to DE with low (100 μ g/m 3) and …

Diesel exhaust particles and their effect on induced cytokine expression in human bronchial epithelial cells

H Takizawa - Current opinion in allergy and clinical immunology, 2004 - journals.lww.com
Host responses to DEPs are regulated by a balance between antioxidants and
proinflammatory responses. DEP-induced oxidants play a key role in proinflammatory …

Induction of Inflammatory Response of Mice Exposed to Diesel Exhaust Is Modulated by CD4+ and CD8+ T Cells

H Fujimaki, N Ui, T Endo - … journal of respiratory and critical care …, 2001 - atsjournals.org
Exposure to diesel exhaust (DE) increased airway inflammatory responses and airway
responsiveness to allergen challenge. To clarify the roles of T cells in DE exposure–induced …