Potential therapeutic relevance of adenosine A2B and A2A receptors in the central nervous system
P Popoli, R Pepponi - … (Formerly Current Drug Targets-CNS & …, 2012 - ingentaconnect.com
Adenosine A2B and, much more importantly, adenosine A2A receptors modulate many
physiological and pathological processes in the brain. In this review, the most recent …
physiological and pathological processes in the brain. In this review, the most recent …
[HTML][HTML] Adenosine receptors and brain diseases: neuroprotection and neurodegeneration
Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …
Molecular and Structural Insight into Adenosine A2A Receptor in Neurodegenerative Disorders: A Significant Target for Efficient Treatment Approach
All biological tissues and bodily fluids include the autacoid adenosine. The P1 class of
purinergic receptors includes adenosine receptors. Four distinct G-protein-coupled …
purinergic receptors includes adenosine receptors. Four distinct G-protein-coupled …
Brain adenosine receptors as targets for therapeutic intervention in neurodegenerative diseases
MP Abbracchio, F Cattabeni - Annals of the New York academy …, 1999 - Wiley Online Library
Adenosine acts as a neurotransmitter in the brain through the activation of four specific G‐
protein‐coupled receptors (the A1, A2A, A2B, and A3 receptors). The A1 receptor has long …
protein‐coupled receptors (the A1, A2A, A2B, and A3 receptors). The A1 receptor has long …
Adenosine A1 receptor: analysis of the potential therapeutic effects obtained by its activation in the central nervous system
A Dalpiaz, S Manfredini - Current medicinal chemistry, 2002 - ingentaconnect.com
Adenosine modulates several physiological functions in the CNS and in peripheral tissues
via membrane receptors which have been classified into four adenosine subtypes. A1 …
via membrane receptors which have been classified into four adenosine subtypes. A1 …
The mouse brain adenosine A1 receptor: functional expression and pharmacology
MC Wittendorp, JFD Künzel, AP Ijzerman… - European journal of …, 2004 - Elsevier
The adenosinergic system is involved in many important physiological functions. Adenosine
exerts its extracellular effects through four types of G-protein-coupled receptors: A1, A2A …
exerts its extracellular effects through four types of G-protein-coupled receptors: A1, A2A …
Dual actions of A2A adenosine receptor antagonists on motor dysfunction and neurodegenerative processes
E Ongini, A Monopoli, F Impagnatiello… - Drug development …, 2001 - Wiley Online Library
Of the four known adenosine receptors, the A2A receptor has received much attention over
the last few years. The discovery of high‐affinity and selective A2A adenosine receptor …
the last few years. The discovery of high‐affinity and selective A2A adenosine receptor …
Adenosine A2A receptors and neuroprotection.
E Ongini, M Adami, C Ferri… - Annals of the New York …, 1997 - europepmc.org
The adenosine A2A receptor subtype is one of the four adenosine receptors that have been
identified in the mammalian organism. In addition to being found in blood vessels, platelets …
identified in the mammalian organism. In addition to being found in blood vessels, platelets …
Adenosine receptors in the nervous system: pathophysiological implications
JA Ribeiro, AM Sebastiao, A De Mendonça - Progress in neurobiology, 2002 - Elsevier
Adenosine is a ubiquitous homeostatic substance released from most cells, including
neurones and glia. Once in the extracellular space, adenosine modifies cell functioning by …
neurones and glia. Once in the extracellular space, adenosine modifies cell functioning by …
[HTML][HTML] A2A adenosine receptor antagonists in neurodegenerative diseases
Background: Alzheimer's disease (AD) is the most common form of dementia worldwide,
with approximately 6 million cases reported in America in 2020. The clinical signs of AD …
with approximately 6 million cases reported in America in 2020. The clinical signs of AD …