Acute lung injury (ALI) causes significant morbidity and mortality. Fibroproliferation in ALI
results in worse outcomes, but the mechanisms governing fibroproliferation remain poorly …

CXC chemokine receptor 3 (CXCR3) is the receptor for the IFN-γ–inducible CXC
chemokines MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11. CXCR3 is expressed on …

The chemokine, CXCL10, and its cognate receptor, CXCR3, are important mediators of the
pathobiology of lung fibrosis. Macrophages are a known source of CXCL10, but their …

We have previously shown that mice that are genetically deficient in the CCR2 gene
(CCR2−/− mice) are protected from fluorescein isothiocyanate (FITC)-induced lung fibrosis …

Bone marrow-derived cells are known to play important roles in repair/regeneration of
injured tissues, but their roles in pathological fibrosis are less clear. Here, we report a critical …

Restoration of the epithelial barrier following acute lung injury is critical for recovery of lung
homeostasis. After injury, alveolar type II epithelial (ATII) cells spread and migrate to cover …

Accumulating evidence suggests that fibrosis is a multicellular process with contributions
from alveolar epithelial cells (AECs), recruited monocytes/macrophages, and fibroblasts. We …

The alveolar epithelium is characteristically abnormal in fibrotic lung disease, and we
recently established a direct link between injury to the type II alveolar epithelial cell (AEC) …

Background CC chemokine receptor (CCR) 7 is a regulator of dendritic cell and T cell
migration, and its role in tissue wound healing has been investigated in various disease …

TGF-β1 is an important suppressive mediator of inflammation, but it can also drive fibrosis
and remodeling in the lung. In response to intratracheal LPS, neutrophils migrate into the …