Failure of cells to process toxic double-strand breaks (DSBs) constitutes a major intrinsic
source of genome instability, a hallmark of cancer. In contrast with interphase of the cell …

A prerequisite for maintaining genome stability in all cell types is the accurate repair and
efficient signaling of DNA double strand breaks (DSBs). It is believed that DSBs are initially …

The repair of DNA lesions that occur endogenously or in response to diverse genotoxic
stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways …

Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …

ABSTRACT DNA damage checkpoints are cellular mechanisms that protect the integrity of
the genome during cell cycle progression. In response to genotoxic stress, these …

Mitosis is controlled by a complex series of signaling pathways but mitotic control following
DNA damage remains poorly understood. Effective DNA damage sensing and repair is …

DNA double-strand breaks (DSBs) are highly toxic lesions that can lead to chromosomal
instability if they are not repaired correctly. DSBs are especially dangerous in mitosis when …

Double‐strand breaks (DSB s) are one of the severest types of DNA damage. Unrepaired
DSB s easily induce cell death and chromosome aberrations. To maintain genomic stability …

DNA double-strand breaks (DSBs) are highly hazardous for genome integrity, because
failure to repair them can lead to genome rearrangements or chromosome loss. They can …

DNA double-strand breaks (DSBs) prevent cells from entering mitosis allowing cells to repair
their genomic damage. Little is known about the response to DSBs once cells have already …