Background Male breast cancer (MBC) represents a poorly characterised group of tumours,
the management of which is largely based on practices established for female breast …

Early age at onset of breast cancer (eoBC) is suggestive of an increased genetic risk.
Although genetic testing is offered to all eoBC-affected women, in isolated cases the …

Introduction Epigenetic gene silencing is one of the major causes of inactivation of tumor-
suppressor genes in many human cancers. Materials and methods The aim of the present …

Promoter-CpG island hypermethylation has been proposed as an alternative mechanism to
inactivate BRCA1 in the breast where somatic mutations of BRCA1 are rare. To better …

Breast cancer is fast emerging as the leading cancer amongst females, especially in young
females in metropolitan cities in India. The epigenetic alterations involved in the onset and …

The role of gene-specific methylation in white blood cells (WBC) as a marker of breast
cancer risk is currently unclear. We determined whether promoter hypermethylation in blood …

OBJECTIVES: The aim of our study was to evaluate the prognostic significance of RASSF1A
promoter methylation status in operable breast cancer. DESIGN AND METHODS: By using …

Background: Promoter hypermethylation and global hypomethylation in the human genome
are hallmarks of most cancers. Detection of aberrant methylation in white blood cells (WBC) …

Previously, we reported that the accuracy of cytological diagnosis of breast lesions could be
augmented through the quantitative assessment of DNA methylation of fine-needle aspirate …

Background Epigenetic studies demonstrate that an association may exist between
methylation of the retinoic acid receptor beta2 (RARβ2) gene promoter and breast cancer …