Rheumatoid arthritis (RA) is a chronic joint inflammatory disease that is closely associated
with dysregulation of fibroblast-like synoviocytes (FLSs). Protocatechuic acid (PCA), a …

Background The aggressive phenotype of fibroblast-like synoviocytes (FLSs) is essential in
the synovitis and bone destruction in rheumatoid arthritis (RA). Punicalagin is a natural …

Rheumatoid arthritis (RA) is a chronic inflammatory disease that mainly targets the synovial
membrane, thus causing stiffness, deformity and dysfunction of joints. To date, no effective …

Honeycomb (Nidus vespae) is traditional Chinese medicine and can treat rheumatoid
arthritis (RA), and protocatechuic acid (PCA) is a bioactive component of honeycomb. This …

Abstract Background Fibroblast‐like synoviocytes (FLSs) play an essential role in the
chronic inflammatory process of rheumatoid arthritis (RA). Carvacrol is a natural …

Caffeic acid (CA) is a phenolic acid widely found in fruits and plants, which exhibits anti-
oxidative, anti-inflammatory, anti-tumor and immunomodulatory properties. Because …

Rheumatoid arthritis fibroblast‐like synoviocytes (RA‐FLSs), a pathological hallmark of
rheumatoid arthritis (RA), exhibit the characteristics of tumor cells. The extracts of Cirsium …

Activated fibroblast-like synoviocytes (FLSs) play a crucial role in the pathogenesis and
progression of rheumatoid arthritis (RA). It is urgent to develop new drugs that can effectively …

Synovial inflammation plays an important role in the pathogenesis and progress of
osteoarthritis (OA). There is an urgent need to find safe and effective drugs that can reduce …

Background Activated fibroblast-like synoviocyte (FLS) played a significant role in the
pathogenesis and progression of rheumatoid arthritis (RA). Apigenin-4′-O-α-L-rhamnoside …