Enteroendocrine cells: sensing gut microbiota and regulating inflammatory bowel diseases

Y Yu, W Yang, Y Li, Y Cong - Inflammatory bowel diseases, 2020 - academic.oup.com
Host sensing in the gut microbiota has been crucial in the regulation of intestinal
homeostasis. Although inflammatory bowel diseases (IBDs), multifactorial chronic …

[HTML][HTML] Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity

JJ Worthington, F Reimann, FM Gribble - Mucosal immunology, 2018 - Elsevier
The intestinal epithelium must balance efficient absorption of nutrients with partitioning
commensals and pathogens from the bodies' largest immune system. If this crucial barrier …

Enteroendocrine cells: neglected players in gastrointestinal disorders?

GW Moran, FC Leslie, SE Levison… - Therapeutic …, 2008 - journals.sagepub.com
Enteroendocrine cells (EEC) form the basis of the largest endocrine system in the body.
They secrete multiple regulatory molecules which control physiological and homeostatic …

[HTML][HTML] The role of microbiota and enteroendocrine cells in maintaining homeostasis in the human digestive tract

D Woźniak, W Cichy, J Przysławski… - Advances in medical …, 2021 - Elsevier
The microbiota is a heterogeneous ecosystem consisting of diverse microorganisms unique
to an individual, playing a crucial role in maintaining human body homeostasis. The …

The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory disease

JJ Worthington - Biochemical Society Transactions, 2015 - portlandpress.com
The intestinal epithelium represents one of our most important interfaces with the external
environment. It must remain tightly balanced to allow nutrient absorption, but maintain …

Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity

AT Soderholm, VA Pedicord - Immunology, 2019 - Wiley Online Library
The intestinal epithelium forms a barrier between the microbiota and the rest of the body. In
addition, beyond acting as a physical barrier, the function of intestinal epithelial cells (IEC s) …

[HTML][HTML] The influence of the gut microbiome on host metabolism through the regulation of gut hormone release

AM Martin, EW Sun, GB Rogers, DJ Keating - Frontiers in physiology, 2019 - frontiersin.org
The microbial community of the gut conveys significant benefits to host physiology. A clear
relationship has now been established between gut bacteria and host metabolism in which …

The intestinal epithelial barrier in the control of homeostasis and immunity

M Rescigno - Trends in immunology, 2011 - cell.com
In the intestine, multiple interactions occur with the external world. Thus, the intestinal
mucosal barrier has to tolerate millions of microorganisms that commonly inhabit the gut …

[HTML][HTML] Roles of intestinal epithelial cells in the maintenance of gut homeostasis

R Okumura, K Takeda - Experimental & molecular medicine, 2017 - nature.com
The intestine is a unique organ inhabited by a tremendous number of microorganisms.
Intestinal epithelial cells greatly contribute to the maintenance of the symbiotic relationship …

Gut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel disease

M Markandey, A Bajaj, NE Ilott, S Kedia, S Travis… - Gut …, 2021 - Taylor & Francis
Intestinal epithelium represents a dynamic and diverse cellular system that continuously
interacts with gut commensals and external cues. Intestinal stem cells, which lie at the heart …