Background Gene targeted therapy refers to any therapy focused on one of the many
biological features of the tumor. Such features are mediated by specific genes that are …

Suppressor of cytokine signaling 3 (SOCS3) is a major negative regulator of signal
transducer and activator of transcription 3 (STAT3) during tumorigenesis. Previous studies …

Hypoxia is an important factor in tumor angiogenesis, metastasis, and resistance to
chemotherapy or radiotherapy, and may be an indicator of poor prognosis. The transcription …

Objectives: Hypoxia is associated with human non-small cell lung cancers (NSCLC), which
are highly resistant to chemotherapy. The hypoxia inducible factor (HIF) as a transcription …

Lung cancer, specifically non-small cell lung cancer (NSCLC), is the leading cause of
cancer‑associated mortality in the world. In previous years, almost no significant …

Hypoxia-inducible factor-2 alpha (HIF-2α) has been shown to regulate cell stemness,
although the expression and effects of HIF-2α in lung cancer stem cells remained unclear …

Abstract Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that play
crucial roles in the adaptation of cancer cells to hypoxia. HIF-1α overexpression has been …

Background Hypoxia-inducible factor 1α (HIF-1α) is a transcription factor that plays an
important role in tumor growth by regulating the energy metabolism and angiogenesis. We …

Background Hypoxia-inducible factor-1 alpha (HIF-1α) maybe an important regulatory factor
for angiogenesis of small cell lung cancer (SCLC). Our study aimed to investigate the effect …

Objective To explore HIF1α and HIF2α regulate the dedifferentiation of lung cancer cells
under hypoxic conditions through Sox2 and Oct4. Materials and methods: HIF1α, HIF2α …