Cholesterol gallstone disease is one of the most common digestive diseases, with an overall
prevalence of 10–20%. Although a common and economically-relevant problem in …

Abstract Background and Aim: The excretion of cholesterol from the liver is regulated by the
ATP‐binding cassette transporter ABCG8. A common genetic polymorphism D19H of …

Background Adenosine triphosphate-binding cassette (ABC) transporters ABCG5 and
ABCG8 are sterol export pumps regulating biliary cholesterol excretion. The formation of …

The sterolin locus (ABCG5/ABCG8) confers susceptibility for cholesterol gallstone disease in
humans. Both the responsible variant and the molecular mechanism causing an increased …

Abstract Background and Aim: Gallstone formation is characterized by the abnormal
regulation of cholesterol trafficking and solubilization. The prevalence of gallstone disease …

Background Gallstone disease is associated with p. D19H of ABCG8 as well as alterations
of cholesterol and bile acid metabolism. However, molecular mechanisms have not been …

BACKGROUND: The role of ABCG5 and ABCG8 genes in the determination of plasma lipid
levels is currently under intensive investigation. The aim of this study was to evaluate …

The regulation of biliary cholesterol secretion by hepatocytes has received much interest [1],
since it has a major impact on two highly relevant disease complexes, namely, the …

Background: Gallbladder cancer (GBC) usually arises against the background of gallstone
disease, which may be causatively related to supersaturation of cholesterol in bile. An …

In the formation of cholesterol gallstones, cholesterol hypersecretion into bile causing
cholesterol supersaturation and crystallization appears to be the primary factor, with …