Abstract Glypican-1 (GPC-1) is a cell surface heparan sulphate proteoglycan that is critical
during normal development, but which is not required for normal homoeostasis in the adult …

Abstract Glypican-3 (GPC3) encodes a cell-surface heparan-sulfate proteoglycan and its
expression is frequently silenced in ovarian cancer, mesotheliomas, and breast cancer cell …

Wnt signaling is important for cancer pathogenesis and is often up‐regulated in
hepatocellular carcinoma (HCC). Heparan sulfate proteoglycans (HSPGs) function as …

Abstract Glypican-3 (GPC3) is a cell-surface glycoprotein that is frequently overexpressed in
hepatocellular carcinoma (HCC). GPC3 undergoes extensive posttranslational modification …

Abstract Purpose and Experimental Design: We recently identified glypican-3 (GPC3)
overexpressed specifically in human hepatocellular carcinoma, as based on cDNA …

Abstract Glypican 3 (GPC3) is a valuable diagnostic marker and a potential therapeutic
target in hepatocellular carcinoma (HCC). To evaluate the efficacy of targeting GPC3 at the …

Glypican-1 (GPC-1) and other glypicans are a family of heparan sulfate proteoglycans.
These proteins are highly expressed on the cell membrane and in the extracellular matrix …

Hepatocellular carcinoma (HCC) has a high morbidity and mortality rate worldwide, with
limited treatment options. Glypican-3 (GPC3) is a glycosylphosphatidylinositol-anchored …

Abstract Glypican-3 (GPC3) mRNA and protein are expressed in> 80% of human
hepatocellular carcinomas (HCC) but not in normal tissues except for placenta and fetal …

Glypicans are a family of heparan sulfate proteoglycans whose members are bound to the
cell surface by a glycosylphosphatidylinositol (GPI) anchor. Loss-of-function mutations in …