Abstract Glypican-3 (GPC3) is a membrane-bound heparan sulfate proteoglycan that is
mutated in the Simpson-Golabi-Behmel syndrome. This is an X-linked condition …

Germ cell tumors (GCTs), rare malignancies that occur in a wide range of locations and
display variable histologic patterns, may pose diagnostic challenges. Glypican 3 (GPC3), a …

Background Glypican-3 (GPC-3) is an oncofetal protein that is highly expressed in various
solid tumors, but rarely expressed in healthy adult tissues and represents a rational target of …

Background: Osteosarcoma (OSA) is a highly metastatic pediatric bone tumor. Adjuvant
chemotherapy and surgical resection represent standard treatments; however, the prognosis …

The Glypican (GPC) family is a prototypical member of the cell‐surface heparan sulfate
proteoglycans (HSPGs). The HSPGs have been demonstrated to interact with growth factors …

G protein-coupled receptors (GPCRs) constitute the largest and most diverse protein family
in the human genome with over 800 members identified to date. They play critical roles in …

Several studies have shown that glypican 3 (GPC3) could be a useful diagnostic marker for
hepatocellular carcinoma (HCC) and for differentiating HCC from nonneoplastic and …

Over the last decade, immunotherapy has rapidly changed the therapeutic landscape and
prognosis for many hematologic malignancies and adult solid tumors. Despite this success …

Abstract Glypican-3 (gpc3) is the gene responsible for Simpson-Golabi-Behmel overgrowth
syndrome. Previously, we have shown that GPC3 is overexpressed in hepatocellular …

Glypican‐3 (GPC3) is an onco‐fetal antigen that is overexpressed in human hepatocellular
carcinoma (HCC), and is only expressed in the placenta and embryonic liver among normal …