Mitochondrial functions and telomere functions have mostly been studied independently. In
recent years, it, however, has become clear that there are intimate links between …

Telomerase has cellular functions beyond telomere stabilization, including a role in
mitochondria. The function of the catalytic component—TERT—in mitochondria is still …

Cellular senescence is an irreversible cell arrest process, which is determined by a variety of
complicated mechanisms, including telomere attrition, mitochondrial dysfunction, metabolic …

Telomerase canonical activity at telomeres prevents telomere shortening, allowing
chromosome stability and cellular proliferation. To perform this task, the catalytic subunit …

Mitochondrial dysfunctions play major roles in many diseases. However, how mitochondrial
stresses are relayed to downstream responses remains unclear. Here we show that the RNA …

Telomerase plays an important role in cellular proliferation capacity and survival under
conditions of stress. A large part of this protective function is due to telomere capping and …

Aging is a biological process characterized by a progressive functional decline in tissues
and organs, which eventually leads to mortality. Telomeres, the repetitive DNA repeat …

Senescence is defined as a stress-induced durable cell cycle arrest. We herein revisit the
origin of two of these stresses, namely mitochondrial metabolic compromise, associated with …

Telomerase is a ribonucleoprotein that counteracts telomere shortening and can immortalise
human cells. There is also evidence for a telomere-independent survival function of …

Human telomerase reverse transcriptase (hTERT) is localized to mitochondria, as well as
the nucleus, but details about its biology and function in the organelle remain largely …