It is well established that mRNA steady‐state levels do not directly correlate with
transcription rate. This is attributed to the multiple post‐transcriptional mechanisms, which …

Differential mRNA stability plays an important role in the regulation of gene expression.
Several recent advances have helped to define the general pathways by which mRNA is …

Studies of yeast transcription have revealed the widespread distribution of intergenic RNA
polymerase II transcripts. These cryptic unstable transcripts (CUTs) are rapidly degraded by …

The analysis of 17 functional mRNAs and two recombinant mRNAs in the yeast
Saccharomyces cerevisiae suggests that the length of an mRNA influences its half-life in this …

When translating mRNAs are cleaved in protein-coding regions, 5′ fragments of mRNAs
are detached from stop codons (ie, nonstop mRNAs) and protected from 3′-5 …

Studies of nonsense-mediated mRNA decay in mammalian cells have proffered unforeseen
insights into changes in mRNA–protein interactions throughout the lifetime of an mRNA …

As the site of gene expression and regulation, the nucleus is the control center of the cell. It
might be thought that degradation of nuclear contents is strictly 'off-limits,'given the …

Abstract mRNA decay is a major determinant of gene expression. In Escherichia coli,
message degradation initiates with an endoribonucleolytic cleavage followed by …

Although it is universally accepted that protein synthesis occurs in the cytoplasm, the
possibility that translation can also take place in the nucleus has been hotly debated …

Polyadenylation in eukaryotes is conventionally associated with increased nuclear export,
translation, and stability of mRNAs. In contrast, recent studies suggest that the Trf4 and Trf5 …