Mechanistic understanding of mammalian mRNA turnover remains incomplete. We
demonstrate that the 3′ to 5′ exoribonuclease decay pathway is a major contributor to …

The nuclear envelope (NE) serves as a central organizing unit for the eukaryotic cell. By
virtue of its highly selective, semipermeable barrier function, the NE shields the enclosed …

Eukaryotic cells have quality control systems that eliminate nonfunctional rRNAs with
deleterious mutations (nonfunctional rRNA decay, NRD). We have previously reported that …

Summary The Nrd1-Nab3-Sen1 (NNS) complex is essential for controlling pervasive
transcription and generating sn/snoRNAs in S. cerevisiae. The NNS complex terminates …

Ribonucleic acid (RNA) homeostasis is dynamically modulated in response to changing
physiological conditions. Tight regulation of RNA abundance through both transcription and …

Two main principles of nuclear organization have been outlined on the basis of contributions
by many research groups in recent years. The first principle is that interphase chromosomes …

Maintaining proper mRNA levels is a key aspect in the regulation of gene expression. The
balance between mRNA synthesis and decay determines these levels. We demonstrate that …

Regulated mRNA turnover is a highly important process in control of gene expression. The
specific sequence elements in mRNA modulate the stability of different mRNAs, which varies …

The control of RNA synthesis from protein‐coding genes is fundamental in determining the
various cell types of higher eukaryotes. The activation of these genes is driven by promoter …