MYC can be considered to be one of the most pressing and important targets for the
development of novel anti-cancer therapies. This is due to its frequent dysregulation in …

Abstract MYC proteins (c-MYC, MYCN, and MYCL) regulate processes involved in many if
not all aspects of cell fate. Therefore, it is not surprising that the MYC genes are deregulated …

MYC is a master transcriptional regulator that controls almost all cellular processes. Over the
last several decades, researchers have strived to define the context-dependent …

The MYC oncoprotein functions as a master regulator of cellular transcription and executes
non-transcriptional tasks relevant to DNA replication and cell cycle regulation, thereby …

MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its
mechanism of action and targets are not completely elucidated, it has a fundamental role in …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …

Summary c-MYC controls global gene expression and regulates cell proliferation, cell
differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is …

MYC, a well-studied proto-oncogene that is overexpressed in> 20% of tumors across all
cancers, is classically known as “undruggable” due to its crucial roles in cell processes and …

Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and
proliferation. As such, most human cancers differ from normal counterpart tissues by a …

Cancer comprises a heterogeneous disease, characterized by diverse features such as
constitutive expression of oncogenes and/or downregulation of tumor suppressor genes …