Background Fragile X syndrome is caused by loss of function of the fragile X mental
retardation 1 (FMR1) gene and shares multiple phenotypes with autism. We have previously …

Recent work has demonstrated the impact of dysfunction of the GABAergic signaling system
in brain and the resultant behavioral pathologies in subjects with autism. In animal models …

Background Fragile XS yndrome, the most common single gene cause of autism, results
from loss of the RNA‐binding protein FMRP. Although FMRP is highly expressed in neurons …

Fragile X syndrome is the most common inherited form of mental retardation and autism. It is
caused by a reduction or elimination of the expression of fragile X mental retardation protein …

Background Candidate genes associated with idiopathic forms of autism overlap with other
disorders including fragile X syndrome. Our laboratory has previously shown reduction in …

Fragile X mental retardation protein (FMRP) is a RNA binding protein, the absence of which
due to silencing of the FMR1 gene causes fragile X syndrome, an X-linked …

Fragile X mental retardation protein (FMRP) is an RNA binding protein with 842 target
mRNAs in mammalian brain. Silencing of the fragile X mental retardation 1 (FMR1) gene …

Fragile X Syndrome is the most common inherited cause of autism. Fragile X mental
retardation protein (FMRP), which is absent in fragile X, is an mRNA binding protein that …

In individuals with fragile X syndrome (FXS), there is a silencing of the fragile X mental
retardation (FMR1) gene, usually due to an expansion of a CGG repeat in the 5'untranslated …

Abstract Background Fragile X syndrome (FXS), the most common genetic cause of autism
spectrum disorder and intellectual disability, is caused by the lack of fragile X mental …