Treatment of sepsis and septic shock remains a clinical conundrum. Recent prospective
trials with anti-cytokine and anti-inflammatory therapies have shown only modest clinical …

The treatment of sepsis and septic shock remains a clinical conundrum, and recent
prospective trials with biological response modifiers aimed at the inflammatory response …

Apoptosis is an important mechanism during the immunopathogenesis of sepsis. Early
programmed cell death of lymphocytes substantially impairs innate and adaptive immunity …

Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
response to infection that leads to uncontrolled inflammatory response followed by …

Over time it has become clear that, much like other organ systems, the function and
responsiveness of the immune system is impaired during the course of sepsis and that this is …

Sepsis is the leading cause of morbidity and mortality in critically ill patients in many
intensive care units. The pathophysiology of organ failure and death in patients with sepsis …

Sepsis, a widely prevalent disease with increasing morbidity and mortality, is thought to
result from uncontrolled inflammatory responses to microbial infection and/or components …

Sepsis demonstrates a marked dysregulation of the immune system in its ability to fight
infection. Previous models have focused on the mechanisms which upregulate and sustain …

Patients with sepsis have impaired host defenses that contribute to the lethality of the
disorder. Recent work implicates lymphocyte apoptosis as a potential factor in the …

Sepsis is the leading cause of death in surgical intensive care units and is a major cause of
morbidity and mortality in neonatal and medical intensive care units. The Centers for …